Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20843171 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EATMMEN1KMT2A | |
| SCHEMBL12504038 | 0.82 | HRH3 (0.56) | SMN1; SMN2KDM4EATMMEN1KMT2A | |
| SCHEMBL27883986 | 0.80 | ACHE (0.55) | SIGMAR1HRH3ACHE | |
| SCHEMBL4592063 | 0.79 | ALDH1A1 (0.54) | KDM4ESIGMAR1HRH3ALDH1A1ACHE | |
| SCHEMBL1505926 | 0.79 | — | — | |
| SCHEMBL3667779 | 0.79 | ALDH1A1 (0.58) | SIGMAR1GAAHRH3LMNAALDH1A1 | |
| SCHEMBL349053 | 0.78 | CCR3 (0.71) | KDM4EATMSIGMAR1GAAALDH1A1 | |
| SCHEMBL20804048 | 0.78 | HRH3 (0.59) | SMN1; SMN2MEN1KMT2AHRH3LMNA | |
| SCHEMBL12412713 | 0.78 | HRH3 (0.52) | MEN1KMT2ASIGMAR1HRH3ACHE | |
| SCHEMBL621695 | 0.78 | HRH3 (0.62) | SMN1; SMN2MEN1KMT2ASIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250552-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2019-03-27 | — | — | EP | disclosed |