Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20843270 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EATMMEN1KMT2A | |
| SCHEMBL21604394 | 0.81 | ALDH1A1 (0.62) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL21820699 | 0.81 | ALDH1A1 (0.64) | KDM4EMEN1KMT2ASIGMAR1ALDH1A1 | |
| SCHEMBL3156587 | 0.80 | LMNA (0.59) | SIGMAR1ALDH1A1LMNAHRH3 | |
| SCHEMBL25856039 | 0.80 | HRH3 (0.50) | MEN1KMT2AALDH1A1RAB9AHRH3 | |
| SCHEMBL2735346 | 0.80 | CCR3 (0.71) | KDM4EATMGAASIGMAR1ALDH1A1 | |
| SCHEMBL20843121 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EATMMEN1KMT2A | |
| SCHEMBL13293323 | 0.78 | HRH3 (0.69) | SMN1; SMN2KDM4EATMMEN1KMT2A | |
| SCHEMBL24307299 | 0.77 | NCF1 (0.65) | MEN1KMT2AALDH1A1HRH3 | |
| SCHEMBL25531006 | 0.77 | TEAD1 (0.52) | MEN1KMT2ASIGMAR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250552-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2019-03-27 | — | — | EP | disclosed |