Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PARL | Q9H300 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9918967 | 0.76 | CFTR (0.39) | CFTRGOPCRAB9ABRD4APP | |
| SCHEMBL26202934 | 0.71 | KCNH2 (0.35) | CFTRGOPCRAB9ASMN1; SMN2APP | |
| SCHEMBL28396338 | 0.70 | BRD4 (0.38) | CFTRGOPCBRD4KDM4ERCE1 | |
| SCHEMBL9800255 | 0.64 | PARL (0.41) | CFTRGOPCRAB9ABRD4SMN1; SMN2 | |
| SCHEMBL9319064 | 0.63 | NPC1 (0.35) | CFTRGOPCRAB9ABRD4SMN1; SMN2 | |
| SCHEMBL7959486 | 0.61 | NPC1 (0.52) | CFTRGOPCRAB9ASMN1; SMN2LMNA | |
| SCHEMBL26769639 | 0.60 | NPC1 (0.32) | RAB9ABRD4APPNR1H2NR1H3 | |
| SCHEMBL14560459 | 0.59 | NR1H2 (0.69) | KDM4ERCE1NR1H2NR1H3LMNA | |
| Biphenyl SCHEMBL15657385 | 0.59 | ALDH1A1 (0.60) | CFTRGOPCRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL25162957 | 0.58 | HPGD (0.53) | BRD4HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019060693-A1 | CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2019-03-28 | — | — | WO | disclosed |