Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARL | Q9H300 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9918967 | 0.84 | CFTR (0.39) | PARLALDH1A1RAB9ABRD4NPC1 | |
| SCHEMBL18194345 | 0.68 | ALDH1A1 (0.37) | ALDH1A1PKM | |
| SCHEMBL9319064 | 0.67 | NPC1 (0.35) | PARLALDH1A1RAB9ABRD4SMN1; SMN2 | |
| SCHEMBL9320291 | 0.67 | BRD4 (0.34) | ALDH1A1RAB9ABRD4SMN1; SMN2PKM | |
| SCHEMBL10284043 | 0.65 | SMN1; SMN2 (0.53) | ALDH1A1RAB9ASMN1; SMN2PKMRECQL | |
| SCHEMBL9581409 | 0.65 | KMT2A (0.32) | ALDH1A1 | |
| SCHEMBL20845647 | 0.64 | SHMT2 (0.36) | PARLRAB9ABRD4SMN1; SMN2NPC1 | |
| SCHEMBL9581412 | 0.64 | KMT2A (0.31) | ALDH1A1RAB9ANPC1 | |
| Biphenyl SCHEMBL28062042 | 0.64 | BRD4 (0.68) | PARLALDH1A1RAB9ABRD4SMN1; SMN2 | |
| SCHEMBL10198086 | 0.64 | MAT2A (0.45) | PARLALDH1A1RAB9ASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417143-A1 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1991-03-20 | — | — | EP | disclosed |
| WO-1989011856-A2 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1989-12-14 | — | — | WO | disclosed |