SCHEMBL208466

SCHEMBL208466

O=C1c2cccc(F)c2C(=O)C1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
SRD5A1 P18405 2/20 0.37
CYP19A1 P11511 2/20 0.36
AKR1A1 P14550 1/20 0.36
AKR1B1 P15121 1/20 0.36
SMARCA2 P51531 1/20 0.35
SMARCA4 P51532 1/20 0.35
PBRM1 Q86U86 1/20 0.35
DDB1 Q16531 1/20 0.35
CRBN Q96SW2 1/20 0.35
PDK2 Q15119 1/20 0.33
DAO P14920 1/20 0.33
DDO Q99489 1/20 0.33
TTR P02766 1/20 0.33
TNKS2 Q9H2K2 1/20 0.33
S100A4 P26447 1/20 0.32
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8733810 0.78 CA1 (0.43) CA1CA2CA7CA9CYP19A1
SCHEMBL28350317 0.75 CA1 (0.38) CA1CA2CA7CA9
SCHEMBL14939430 0.73 MAPT (0.62) CA1CA2CA7CA9CYP19A1
SCHEMBL10716838 0.70 MAOA (0.52) CA1CA2CA7CA9AKR1A1
SCHEMBL13487412 0.70 CA1 (0.52) CA1CA2CA7CA9AKR1A1
SCHEMBL5866470 0.70 CA1 (0.52) CA1CA2CA7CA9AKR1A1
SCHEMBL9851539 0.69 BACE1 (0.35) CA1CA2CA7CA9SRD5A1
SCHEMBL28619081 0.69 CA1 (0.40) CA1CA2CA7CA9CYP19A1
SCHEMBL22129686 0.69 CA1 (0.48) CA1CA2CA7CA9AKR1A1
SCHEMBL8916299 0.69 MAPT (0.54) CA1CA2CA7CA9AKR1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2213662-B1 AZAINDENOFLUORENEDIONE DERIVATIVE, ORGANIC ELECTROLUMINESCENT DEVICE MATERIAL, AND ORGANIC ELECTROLUMINESCENT DEVICE IDEMITSU KOSAN CO (JP) 2012-04-18 EP disclosed
US-8088901-B2 Azaindenofluorenedione derivative, material for organic electroluminescence device and organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2012-01-03 US disclosed
EP-2213662-A1 AZAINDENOFLUORENEDIONE DERIVATIVE, ORGANIC ELECTROLUMINESCENT DEVICE MATERIAL, AND ORGANIC ELECTROLUMINESCENT DEVICE Idemitsu Kosan Co., Ltd. (JP) 2010-08-04 EP disclosed
US-20090315022-A1 AZAINDENOFLUORENEDIONE DERIVATIVE, MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2009-12-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090315022-A1 AZAINDENOFLUORENEDIONE DERIVATIVE, MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE CYP19A1, HSD17B2, AZI2 CA1 3005/4885CA2 3891/4885CA7 2139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.