Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20848252 | 0.85 | POLB (0.40) | GAAPOLBALDH1A1KMT2AACHE | |
| SCHEMBL20848220 | 0.85 | POLB (0.54) | GAAPOLBALDH1A1KMT2AMAPT | |
| SCHEMBL4966443 | 0.85 | POLB (0.54) | GAAPOLBALDH1A1KMT2AMAPT | |
| SCHEMBL4966437 | 0.85 | POLB (0.54) | GAAPOLBALDH1A1KMT2AMAPT | |
| SCHEMBL8085823 | 0.81 | POLB (0.50) | GAAPOLBALDH1A1KMT2AMAPT | |
| SCHEMBL29576208 | 0.70 | KMT2A (0.45) | RAB9AALDH1A1SMN1; SMN2NPC1KMT2A | |
| SCHEMBL25669125 | 0.68 | RAB9A (0.46) | GAAPOLBRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL11839434 | 0.68 | L3MBTL1 (0.56) | GAAPOLBALDH1A1KMT2AMAPT | |
| SCHEMBL24067983 | 0.67 | KMT2A (0.68) | GAARAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11194594 | 0.67 | KMT2A (0.68) | GAARAB9AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057951-A1 | METHOD FOR PREPARATION OF DIFLUOROMETHYLORNITHINE | LONZA LTD (CH) | 2019-03-28 | — | — | WO | disclosed |