Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20848255 | 0.85 | GAA (0.41) | POLBBCHEACHEBACE1ALDH1A1 | |
| SCHEMBL20848220 | 0.85 | POLB (0.54) | POLBBCHEACHEBACE1ALDH1A1 | |
| SCHEMBL4966437 | 0.85 | POLB (0.54) | POLBBCHEACHEBACE1ALDH1A1 | |
| SCHEMBL4966443 | 0.85 | POLB (0.54) | POLBBCHEACHEBACE1ALDH1A1 | |
| SCHEMBL8085823 | 0.81 | POLB (0.50) | POLBBCHEACHEBACE1ALDH1A1 | |
| SCHEMBL3988927 | 0.68 | ACHE (0.59) | BCHEACHEBACE1ALDH1A1KMT2A | |
| SCHEMBL8210258 | 0.68 | ACHE (0.59) | BCHEACHEBACE1ALDH1A1KMT2A | |
| SCHEMBL11839434 | 0.68 | L3MBTL1 (0.56) | POLBBCHEACHEBACE1ALDH1A1 | |
| SCHEMBL19233519 | 0.67 | KMT2A (0.68) | BCHEACHEBACE1ALDH1A1KMT2A | |
| SCHEMBL26665489 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634943-B1 | METHOD FOR PREPARATION OF DIFLUOROMETHYLORNITHINE | LONZA AG (CH) | 2020-09-09 | — | — | EP | disclosed |
| US-20200148627-A1 | METHOD FOR PREPARATION OF DIFLUOROMETHYLORNITHINE | LONZA LTD (CH) | 2020-05-14 | — | — | US | disclosed |
| WO-2019057951-A1 | METHOD FOR PREPARATION OF DIFLUOROMETHYLORNITHINE | LONZA LTD (CH) | 2019-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148627-A1 | METHOD FOR PREPARATION OF DIFLUOROMETHYLORNITHINE | SMYD3, MCM3, HLCS | POLB 2441/4885BCHE 224/4885ACHE 3567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.