Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966437 | 0.95 | POLB (0.54) | POLBALDH1A1HPGDMAPTGAA | |
| SCHEMBL20848220 | 0.95 | POLB (0.54) | POLBALDH1A1HPGDMAPTGAA | |
| SCHEMBL4966443 | 0.95 | POLB (0.54) | POLBALDH1A1HPGDMAPTGAA | |
| SCHEMBL20848255 | 0.81 | GAA (0.41) | POLBALDH1A1HPGDMAPTGAA | |
| SCHEMBL20848252 | 0.81 | POLB (0.40) | POLBALDH1A1GAAACHEBACE1 | |
| SCHEMBL11839434 | 0.80 | L3MBTL1 (0.56) | POLBALDH1A1HPGDMAPTGAA | |
| SCHEMBL11390399 | 0.79 | POLB (0.40) | POLBHPGDMAPTGAAKDM4E | |
| SCHEMBL11390397 | 0.79 | POLB (0.40) | POLBHPGDMAPTGAAKDM4E | |
| SCHEMBL8778113 | 0.78 | PSEN1 (0.36) | POLBALDH1A1HPGDGAAKDM4E | |
| SCHEMBL7091930 | 0.76 | MAPT (0.43) | ALDH1A1HPGDMAPTTHRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58116468-A | — | — | None | — | — | JP | disclosed |
| JP-58116469-A | — | — | None | — | — | JP | disclosed |
| US-6034215-A | 3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors | CORVAS INTERNATIONAL, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-5703208-A | ANTICOAGULANTS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0802923-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-10-29 | — | — | EP | disclosed |
| WO-1995035311-A9 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | — | 1996-02-01 | — | — | WO | disclosed |
| WO-1995035311-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-28 | — | — | WO | disclosed |
| JP-S58116468-A | OPTICALLY ACTIVE ALPHA-MONOALKYLAMINO-BETA-CAPROLACTAM AND PREPARATION OF ALPHA-MONOALKYLAMINO-EPSILON-CAPRO-LACTAM | TORAY IND INC | 1983-07-11 | — | — | JP | disclosed |
| JP-S58116469-A | ALPHA-SUBSTITUTED METHYLENEAMINO-EPSILON-CAPROLACTAM AND ITS PREPARATION | TORAY IND INC | 1983-07-11 | — | — | JP | disclosed |