SCHEMBL20850078

SCHEMBL20850078

CC1(C)c2cc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4ccccc4)cc3)cnc2-c2sc(C=C(C#N)C#N)cc21

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.36
▸ APP P05067 2/20 0.35
▸ MEN1 O00255 3/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ PTGDR2 Q9Y5Y4 3/20 0.33
▸ ALDH1A1 P00352 2/20 0.32
▸ LMNA P02545 2/20 0.32
▸ HPGD P15428 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20850410 0.96 MAPT (0.34) MAPTAPPMEN1KMT2APTGDR2
SCHEMBL20850071 0.94 MEN1 (0.36) MAPTAPPMEN1KMT2APTGDR2
SCHEMBL20850411 0.94 MAPT (0.33) MAPTAPPMEN1KMT2A
SCHEMBL20850069 0.89 APP (0.32) MAPTAPPMEN1KMT2AALDH1A1
SCHEMBL20850079 0.88 MAPT (0.32) MAPTAPPMEN1KMT2A
SCHEMBL20850308 0.88 MEN1 (0.32) MAPTMEN1KMT2A
SCHEMBL20880886 0.88 MEN1 (0.30) MEN1KMT2A
SCHEMBL20850070 0.87 KDM4E (0.30) MAPTAPPMEN1KMT2AALDH1A1
SCHEMBL20850307 0.86 KDM4E (0.31) MAPTMEN1KMT2A
SCHEMBL20850391 0.84 MAPT (0.36) MAPTAPPMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10947212-B2 Photoelectric conversion element, two-dimensional sensor, image sensor, and image pickup device CANON KABUSHIKI KAISHA (JP) 2021-03-16 — — US disclosed
US-20190092743-A1 PHOTOELECTRIC CONVERSION ELEMENT, TWO-DIMENSIONAL SENSOR, IMAGE SENSOR, AND IMAGE PICKUP DEVICE CANON KABUSHIKI KAISHA (JP) 2019-03-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190092743-A1 PHOTOELECTRIC CONVERSION ELEMENT, TWO-DIMENSIONAL SENSOR, IMAGE SENSOR, AND IMAGE PICKUP DEVICE NR2E3, CRY2, GPR3 MAPT 3800/4885APP 1621/4885MEN1 3080/4885
US-10947212-B2 Photoelectric conversion element, two-dimensional sensor, image sensor, and image pickup device NR2E3, CRY2, GPR3 MAPT 3800/4885APP 1621/4885MEN1 3080/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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