Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CA3 | P07451 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA6 | P23280 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179149 | 0.86 | TPMT (0.56) | TPMTHCAR1ALOX15TSHRHIF1A | |
| Hydrochloric Acid SCHEMBL11078337 | 0.84 | TPMT (0.54) | TPMTHCAR1ALOX15TSHRHIF1A | |
| Hydrochloric Acid SCHEMBL1179035 | 0.84 | TPMT (0.54) | TPMTHCAR1ALOX15TSHRHIF1A | |
| Citrazinic Acid SCHEMBL185046 | 0.84 | TSHR (0.56) | TPMTHCAR1ALOX15TSHRHIF1A | |
| SCHEMBL2714624 | 0.83 | CA5A (0.48) | ALOX15TSHRSMN1; SMN2NPC1RAB9A | |
| Citrazinic Acid SCHEMBL11217659 | 0.81 | TSHR (0.54) | TPMTHCAR1ALOX15TSHRHIF1A | |
| Citrazinic Acid SCHEMBL10818912 | 0.81 | TSHR (0.54) | TPMTHCAR1ALOX15TSHRHIF1A | |
| Citrazinic Acid SCHEMBL28292100 | 0.81 | TSHR (0.54) | TPMTHCAR1ALOX15TSHRHIF1A | |
| SCHEMBL8908899 | 0.80 | TPMT (0.50) | TPMTHCAR1ALOX15TSHRHIF1A | |
| Citrazinic Acid SCHEMBL27862917 | 0.80 | ALOX15 (0.48) | TPMTHCAR1ALOX15TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107602457-A | The method of the aminoisonicotinic acid of 6 methyl of one pot process 2 | 重庆奥舍生物化工有限公司 | 2018-01-19 | — | — | CN | claimed |
| CN-103275110-B | Highly stable Tb coordination polymer green luminous material and preparation method thereof | UNIV LUOYANG NORMAL | 2015-06-03 | — | — | CN | claimed |
| CN-103275110-A | Highly stable Tb coordination polymer green luminous material and preparation method thereof | UNIV LUOYANG NORMAL | 2013-09-04 | — | — | CN | claimed |
| CN-113264945-B | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| EP-3593648-B1 | SWEET FLAVOR MODIFIER | FIRMENICH INCORPORATED (US) | 2021-07-14 | — | — | EP | disclosed |
| EP-2880031-B1 | SWEET FLAVOR MODIFIER | FIRMENICH INCORPORATED (US) | 2020-06-17 | — | — | EP | disclosed |
| CN-106478497-B | Arylamine derivatives as TTX-S blockers | 拉夸里亚创药株式会社 | 2020-05-08 | — | — | CN | disclosed |
| CN-104603132-B | Sweet taste modifier | 弗门尼舍公司 | 2020-02-21 | — | — | CN | disclosed |
| EP-2952503-B1 | CARBOXYLIC ACID DERIVATIVES AS HIV REPLICATION INHIBITOR | SHIONOGI & CO (JP) | 2019-10-23 | — | — | EP | disclosed |
| CN-107602457-A | The method of the aminoisonicotinic acid of 6 methyl of one pot process 2 | 重庆奥舍生物化工有限公司 | 2018-01-19 | — | — | CN | disclosed |
| US-9745293-B2 | Sweet flavor modifier | SENOMYX, INC. (US) | 2017-08-29 | — | — | US | disclosed |
| CN-101321525-A | Heteroaryl substituted piperidine derivatives as L-CPT1 inhibitors | HOFFMANN LA ROCHE (CH) | 2008-12-10 | — | — | CN | disclosed |
| US-7425408-B2 | Silver halide color photographic light-sensitive material | FUJIFILM CORPORATION (JP) | 2008-09-16 | — | — | US | disclosed |
| US-20080153837-A1 | Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-06-26 | — | — | US | disclosed |
| WO-2008014888-A2 | IMINO-IMIDAZO-PYRIDINE DERIVATIVES HAVING ANTITHROMBOTIC ACTIVITY | SANOFI-AVENTIS (FR) | 2008-02-07 | — | — | WO | disclosed |
| EP-1622610-B1 | 1-(2H-PYRAZOL-3-YL)-3-{4-[1-(BENZOYL)-PIPERIDIN-4-YLMETHYL]-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AVENTIS PHARMA INC (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2006064286-A1 | CATHEPSIN S INHIBITORS | MEDIVIR UK LTD (GB) | 2006-06-22 | — | — | WO | disclosed |
| US-20060063796-A1 | Pyrazoles as inhibitors of tumor necrosis factor | AVENTIS PHARMACEUTICALS INC. (US) | 2006-03-23 | — | — | US | disclosed |
| EP-1622610-A1 | 1-(2H-PYRAZOL-3-YL)-3- 4-[1-(BENZOYL)-PIPERIDIN-4-YLMETHYL]-PHENYL -UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | Aventis Pharmaceuticals Inc. (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004100946-A1 | 1- (2H-PYRAZOL -3-YL) -3YL) {4-`1- (BENZOYL) -PIPERIDIN-4-YLMETHYL!-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF IMFLAMMATIONS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063796-A1 | Pyrazoles as inhibitors of tumor necrosis factor | TNF, LITAF, MAPK1 | TPMT 220/4885HCAR1 1619/4885ALOX15 975/4885 |
| US-20080153837-A1 | Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof | HSP90B1, HSP90AB1, HSP90AA1 | TPMT 2192/4885HCAR1 4470/4885ALOX15 3346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.