Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 4/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20854982 | 0.83 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL15933675 | 0.76 | PDCD1 (0.52) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL16003900 | 0.75 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL20854973 | 0.74 | HIF1A (0.45) | NPC1RAB9APDE10A | |
| Hydrochloric Acid SCHEMBL16341551 | 0.74 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL16003886 | 0.71 | NOTUM (0.45) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL16340966 | 0.69 | PDE10A (0.43) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL16320445 | 0.68 | PDE10A (0.58) | PDE10A | |
| SCHEMBL11415064 | 0.67 | SMN1; SMN2 (0.75) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL4839735 | 0.67 | WDR5 (0.71) | NPC1RAB9ASMN1; SMN2TGFBR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975095-B2 | — | — | 2021-04-13 | — | — | US | disclosed |
| US-20190100530-A1 | BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100530-A1 | BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF | HSD17B7, CYP11B1, CYP11B2 | NPC1 192/4885RAB9A 2444/4885SMN1; SMN2 3876/4885 |
| US-10975095-B2 | — | CYP1B1, UGT1A1, CYP4B1 | NPC1 56/4885RAB9A 702/4885SMN1; SMN2 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.