Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20868349 | 0.98 | HTR1A (0.76) | HTR1ASLC6A4 | |
| SCHEMBL20868501 | 0.91 | HTR1A (0.77) | HTR1ASLC6A4 | |
| SCHEMBL20868146 | 0.89 | HTR1A (0.77) | HTR1ASLC6A4 | |
| SCHEMBL16433128 | 0.86 | HTR1A (1.00) | HTR1A | |
| SCHEMBL22371658 | 0.86 | HTR1A (0.61) | HTR1ASLC6A4 | |
| SCHEMBL16432772 | 0.84 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL20868395 | 0.84 | SLC6A4 (0.67) | HTR1ASLC6A4 | |
| SCHEMBL22371656 | 0.84 | SLC6A4 (0.63) | HTR1ASLC6A4 | |
| SCHEMBL18296854 | 0.83 | SLC6A4 (0.81) | HTR1ASLC6A4 | |
| SCHEMBL20868391 | 0.83 | SLC6A4 (0.75) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861182-B | Phosphate of pyrimidine thiazole carboxamide compound and crystal form thereof | 广东东阳光药业股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-114195773-B | Process for the preparation of substituted pyrimidinylpiperazine compounds | 广东东阳光药业股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-3687989-B1 | SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2024-02-28 | — | — | EP | disclosed |
| EP-3687989-B1 | SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2024-02-28 | — | — | EP | disclosed |
| US-20240010643-A1 | PREPARATION METHOD OF SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUNDS | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2024-01-11 | — | — | US | disclosed |
| US-20230312551-A1 | SALT OF 2-(SUBSTITUTED PYRIMIDINYL) THIAZOLE CARBOXAMIDE COMPOUND, AND COMPOSITION AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2023-10-05 | — | — | US | disclosed |
| CN-113861184-B | Phosphate of 2- (substituted pyrimidinyl) thiazole carboxamide compound and use thereof | 广东东阳光药业有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-113861183-B | Salts of substituted pyrimidine piperazine compounds and uses thereof | 广东东阳光药业有限公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-4174065-A1 | SALT OF 2-(SUBSTITUTED PYRIMIDINYL)THIAZOLECARBOXAMIDE COMPOUND, AND COMPOSITION AND USE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2023-05-03 | — | — | EP | disclosed |
| CN-113861185-B | Salts of 2- (substituted pyrimidinyl) thiazolecarboxamide compounds, compositions and uses thereof | 广东东阳光药业有限公司 | 2023-04-07 | — | — | CN | disclosed |
| US-11285153-B2 | Substituted pyrimidine piperazine compound and use thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-03-29 | — | — | US | disclosed |
| WO-2022002011-A1 | SALT OF 2-(SUBSTITUTED PYRIMIDINYL)THIAZOLECARBOXAMIDE COMPOUND, AND COMPOSITION AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2022-01-06 | — | — | WO | disclosed |
| CN-113861183-A | Salts of substituted pyrimidinylpiperazine compounds and uses thereof | 广东东阳光药业有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-113861184-A | Phosphate of 2- (substituted pyrimidinyl) thiazole carboxamide compounds and uses thereof | 广东东阳光药业有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-113861182-A | Phosphate of pyrimidine thiazole carboxamide compound and crystal form thereof | 广东东阳光药业有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-113861185-A | Salts of 2- (substituted pyrimidinyl) thiazole carboxamide compounds, compositions and uses thereof | 广东东阳光药业有限公司 | 2021-12-31 | — | — | CN | disclosed |
| US-20200276196-A1 | SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-09-03 | — | — | US | disclosed |
| US-20200276196-A1 | SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-09-03 | — | — | US | disclosed |
| WO-2019062662-A1 | SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312551-A1 | SALT OF 2-(SUBSTITUTED PYRIMIDINYL) THIAZOLE CARBOXAMIDE COMPOUND, AND COMPOSITION AND USE THEREOF | GRIN2C, GRIN2A, NR3C2 | HTR1A 187/4885SLC6A4 18/4885 |
| US-20240010643-A1 | PREPARATION METHOD OF SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUNDS | UMPS, ITPA, DPYD | HTR1A 1944/4885SLC6A4 3693/4885 |
| US-20200276196-A1 | SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF | HTR5A, TPH1, HTR2C | HTR1A 5/4885SLC6A4 13/4885 |
| US-11285153-B2 | Substituted pyrimidine piperazine compound and use thereof | HTR5A, TPH1, HTR2C | HTR1A 5/4885SLC6A4 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.