Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UQCRB | P14927 | 3/20 | 0.67 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | RORA | P35398 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849569 | 0.83 | MAPT (0.58) | UQCRBPTPN5CA1CA2HSD17B2 | |
| SCHEMBL17849563 | 0.83 | FFAR1 (0.59) | UQCRBPTPN5CA1CA2ALDH1A1 | |
| SCHEMBL7175892 | 0.82 | CES1 (0.62) | HSD17B2ALDH1A1MAPTHSP90AA1HSP90AB1 | |
| SCHEMBL19281326 | 0.82 | PTPN5 (0.81) | UQCRBPTPN5CA1CA2ALDH1A1 | |
| SCHEMBL16187970 | 0.82 | HSD17B2 (0.68) | UQCRBPTPN5CA1CA2HSD17B2 | |
| SCHEMBL10013443 | 0.82 | PTPN5 (0.68) | UQCRBPTPN5CA1CA2HSD17B2 | |
| SCHEMBL812679 | 0.81 | ALDH1A1 (0.83) | UQCRBPTPN5CA1CA2ALDH1A1 | |
| SCHEMBL7178237 | 0.80 | UQCRB (1.00) | UQCRBPTPN5CA1CA2HSD17B2 | |
| SCHEMBL15056053 | 0.80 | PTPN5 (0.66) | UQCRBPTPN5CA1CA2HSD17B2 | |
| SCHEMBL14285600 | 0.80 | MAPT (0.67) | HSD17B2ALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354440-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-01-15 | — | — | US | disclosed |
| US-8268879-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120077759-A1 | 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-29 | — | — | US | disclosed |
| US-8088816-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-03 | — | — | US | disclosed |
| US-8044089-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-25 | — | — | US | disclosed |
| US-20110046367-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-02-24 | — | — | US | disclosed |
| US-7846962-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-12-07 | — | — | US | disclosed |
| US-20100256388-A1 | 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100249201-A1 | 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-09-30 | — | — | US | disclosed |
| US-7737172-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-06-15 | — | — | US | disclosed |
| US-20090299058-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-12-03 | — | — | US | disclosed |
| US-20070099976-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-05-03 | — | — | US | disclosed |
| EP-1718611-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | The President and Fellows of Harvard College (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080335-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256388-A1 | 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation | EIF2AK2, EIF5B, EIF4EBP1 | UQCRB 2424/4885PTPN5 2268/4885CA1 4765/4885 |
| US-20090299058-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | EIF2AK2, EIF5B, EIF4EBP1 | UQCRB 2424/4885PTPN5 2268/4885CA1 4765/4885 |
| US-20070099976-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | EIF2AK2, EIF5B, EIF4EBP1 | UQCRB 2424/4885PTPN5 2268/4885CA1 4765/4885 |
| US-20120077759-A1 | 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation | EIF2AK2, EIF5B, EIF4EBP1 | UQCRB 2424/4885PTPN5 2268/4885CA1 4765/4885 |
| US-20110046367-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | EIF2AK2, EIF5B, EIF4EBP1 | UQCRB 2424/4885PTPN5 2268/4885CA1 4765/4885 |
| US-20100249201-A1 | 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation | EIF2AK2, EIF5B, EIF4EBP1 | UQCRB 2424/4885PTPN5 2268/4885CA1 4765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.