Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 9/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.74 |
| ▸ | CCR6 | P51684 | 1/20 | 0.74 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.74 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.74 |
| ▸ | NR4A1 | P22736 | 7/20 | 0.73 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.72 |
| ▸ | CASP1 | P29466 | 1/20 | 0.72 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340608 | 0.93 | TERT (0.86) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL19721 | 0.93 | TERT (0.86) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL22010844 | 0.93 | TERT (0.86) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL17124740 | 0.92 | TERT (0.85) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL18782118 | 0.91 | TERT (0.84) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL22010937 | 0.90 | TERT (0.82) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL18782152 | 0.90 | TERT (0.82) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL20371753 | 0.89 | TERT (0.80) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL22011618 | 0.89 | TERT (0.79) | TERTHSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL18782151 | 0.87 | TERT (0.78) | TERTHSP90AA1CCR6PAX8TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753436-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753436-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210061851-A1 | ANALOGS OF CELASTROL | ERX PHARMACEUTICALS CORPORATION | 2021-03-04 | — | — | US | disclosed |
| US-10662218-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION | 2020-05-26 | — | — | US | disclosed |
| US-20180194709-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION | 2018-07-12 | — | — | US | disclosed |
| WO-2017070615-A1 | ANALOGS OF CELASTROL | ERX PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | disclosed |
| EP-2609108-B1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | SUZHOU NEUPHARMA CO LTD (CN) | 2015-12-16 | — | — | EP | disclosed |
| WO-2015148802-A1 | CELASTROL AND DERIVATIVES FOR THE TREATMENT OF OBESITY | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2015-10-01 | — | — | WO | disclosed |
| US-20150274634-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION | 2015-10-01 | — | — | US | disclosed |
| US-20150274634-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION | 2015-10-01 | — | — | US | disclosed |
| US-20120052019-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC. | 2012-03-01 | — | — | US | disclosed |
| US-20110166216-A1 | Compositions and Methods for Inhibiting Growth and Metastasis of Melanoma | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2011-07-07 | — | — | US | disclosed |
| US-20110166216-A1 | Compositions and Methods for Inhibiting Growth and Metastasis of Melanoma | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2011-07-07 | — | — | US | disclosed |
| US-7888355-B2 | Compositions and methods for inhibiting growth and metastasis of melanoma | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-02-15 | — | — | US | disclosed |
| US-20100305129-A1 | COMPOSITIONS AND METHODS FOR INHIBITING GROWTH AND METASTASIS OF MELANOMA | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-7776894-B2 | Compositions and methods for inhibiting growth and metastasis of melanoma | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-08-17 | — | — | US | disclosed |
| US-7776894-B2 | Compositions and methods for inhibiting growth and metastasis of melanoma | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-08-17 | — | — | US | disclosed |
| WO-2009026163-A1 | COMPOSITIONS AND METHODS FOR INHIBITING GROWTH AND METASTASIS OF MELANOMA | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-26 | — | — | WO | disclosed |
| US-20090054438-A1 | COMPOSITIONS AND METHODS FOR INHIBITING GROWTH AND METASTASIS OF MELANOMA | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-26 | — | — | US | disclosed |
| US-20090054438-A1 | COMPOSITIONS AND METHODS FOR INHIBITING GROWTH AND METASTASIS OF MELANOMA | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061851-A1 | ANALOGS OF CELASTROL | GIPR, GPR119, EBP | TERT 3225/4885HSP90AA1 123/4885CCR6 3242/4885 |
| US-20180194709-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | GPR119, FABP4, ADIPOR1 | TERT 3318/4885HSP90AA1 2473/4885CCR6 674/4885 |
| US-20100305129-A1 | COMPOSITIONS AND METHODS FOR INHIBITING GROWTH AND METASTASIS OF MELANOMA | API5, ACIN1, MCL1 | TERT 2018/4885HSP90AA1 158/4885CCR6 1953/4885 |
| US-20150274634-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | GPR119, FABP4, ADIPOR1 | TERT 3318/4885HSP90AA1 2473/4885CCR6 674/4885 |
| US-20120052019-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | LTB4R2, PTGER4, PMP22 | TERT 282/4885HSP90AA1 3632/4885CCR6 474/4885 |
| US-10662218-B2 | Analogs of celastrol | GIPR, GPR119, EBP | TERT 3225/4885HSP90AA1 123/4885CCR6 3242/4885 |
| US-11753436-B2 | Analogs of celastrol | GIPR, GPR119, EBP | TERT 3225/4885HSP90AA1 123/4885CCR6 3242/4885 |
| US-20090054438-A1 | COMPOSITIONS AND METHODS FOR INHIBITING GROWTH AND METASTASIS OF MELANOMA | API5, ACIN1, MCL1 | TERT 2018/4885HSP90AA1 158/4885CCR6 1953/4885 |
| US-20110166216-A1 | Compositions and Methods for Inhibiting Growth and Metastasis of Melanoma | API5, ACIN1, MCL1 | TERT 2018/4885HSP90AA1 158/4885CCR6 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.