Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20855556 | 0.87 | KDM4E (0.43) | TSHRSMN1; SMN2GLAKDM4EGAA | |
| SCHEMBL7347046 | 0.79 | ALDH1A1 (0.42) | TSHRKDM4EALDH1A1HTTKMT2A | |
| SCHEMBL20855668 | 0.78 | ADRA2A (0.40) | KDM4EGAAMAPTRAB9ANPC1 | |
| SCHEMBL8324844 | 0.77 | TSHR (0.43) | TSHRSMN1; SMN2GLAKDM4EGAA | |
| SCHEMBL143912 | 0.76 | CYP2D6 (0.49) | KDM4EADRA2AADRA1ATDP1LMNA | |
| SCHEMBL20855486 | 0.76 | CYP2D6 (0.49) | KDM4EADRA2AADRA1ATDP1LMNA | |
| SCHEMBL20855585 | 0.76 | ADRA2A (0.38) | TSHRSMN1; SMN2GLAKDM4EGAA | |
| SCHEMBL6773702 | 0.76 | ALDH1A1 (0.43) | SMN1; SMN2KDM4EMAPTALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL20855876 | 0.75 | MEN1 (0.50) | KDM4EADRA2AADRA1ATDP1LMNA | |
| Hydrochloric Acid SCHEMBL3538526 | 0.75 | MEN1 (0.50) | KDM4EADRA2AADRA1ATDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |