Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989278 | 0.83 | ADRA1A (0.59) | ADRA2AADRA1ACYP2D6MEN1BLM | |
| SCHEMBL20855722 | 0.81 | ADRA2A (0.40) | ADRA2AADRA1ACYP2D6MEN1BLM | |
| SCHEMBL20855556 | 0.81 | KDM4E (0.43) | ADRA2AADRA1ACYP2D6HTTKDM4E | |
| SCHEMBL12363071 | 0.80 | LMNA (0.38) | ADRA2AADRA1AMEN1BLMKMT2A | |
| SCHEMBL20855585 | 0.79 | ADRA2A (0.38) | ADRA2AADRA1ACYP2D6MEN1BLM | |
| SCHEMBL6773702 | 0.79 | ALDH1A1 (0.43) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL3386809 | 0.78 | CA1 (0.43) | HTTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL20869135 | 0.78 | TSHR (0.39) | ADRA2AADRA1AKMT2AHTTKDM4E | |
| SCHEMBL20855843 | 0.78 | KDM4E (0.45) | MEN1KMT2AMAPK1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL382233 | 0.77 | IDO1 (0.45) | KMT2AHTTALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |