Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.57 |
| ▸ | CTSS | P25774 | 4/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 3/20 | 0.55 |
| ▸ | CTSK | P43235 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | ECE1 | P42892 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20854293 | 1.00 | CTSL (0.57) | CTSLCTSSATMCTSBCTSK | |
| SCHEMBL20854292 | 1.00 | CTSL (0.57) | CTSLCTSSATMCTSBCTSK | |
| Hydrochloric Acid SCHEMBL5672176 | 0.99 | CTSL (0.56) | CTSLCTSSATMCTSBCTSK | |
| Hydrochloric Acid SCHEMBL20854193 | 0.99 | CTSL (0.56) | CTSLCTSSATMCTSBCTSK | |
| Hydrochloric Acid SCHEMBL20854290 | 0.99 | CTSL (0.56) | CTSLCTSSATMCTSBCTSK | |
| Hydrochloric Acid SCHEMBL20876819 | 0.99 | CTSL (0.56) | CTSLCTSSATMCTSBCTSK | |
| Formic Acid SCHEMBL28896984 | 0.95 | CTSL (0.53) | CTSLCTSSATMCTSBCTSK | |
| Formic Acid SCHEMBL28896986 | 0.95 | CTSL (0.53) | CTSLCTSSATMCTSBCTSK | |
| SCHEMBL21890679 | 0.90 | TRPM8 (0.60) | CTSLCTSSATMCTSBCTSK | |
| Isopropylamine SCHEMBL10558459 | 0.90 | CTSL (0.59) | CTSLCTSSATMCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210009580-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. | 2021-01-14 | — | — | US | disclosed |
| US-10815228-B2 | Aztreonam derivatives and uses thereof | ARIXA PHARMACEUTICALS, INC. (US) | 2020-10-27 | — | — | US | disclosed |
| US-20190211006-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. | 2019-07-11 | — | — | US | disclosed |
| US-10280161-B2 | Aztreonam derivatives and uses thereof | ARIXA PHARMACEUTICALS, INC. (US) | 2019-05-07 | — | — | US | disclosed |
| WO-2019070595-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. (US) | 2019-04-11 | — | — | WO | disclosed |
| US-20190100516-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280161-B2 | Aztreonam derivatives and uses thereof | MGAM, ABCG2, SI | CTSL 1068/4885CTSS 2631/4885ATM 697/4885 |
| US-20190211006-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | MGAM, ABCG2, SI | CTSL 1068/4885CTSS 2631/4885ATM 697/4885 |
| US-20190100516-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | MGAM, ABCG2, SI | CTSL 1068/4885CTSS 2631/4885ATM 697/4885 |
| US-10815228-B2 | Aztreonam derivatives and uses thereof | MGAM, ABCG2, SI | CTSL 1068/4885CTSS 2631/4885ATM 697/4885 |
| US-20210009580-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | MGAM, ABCG2, SI | CTSL 1068/4885CTSS 2631/4885ATM 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.