Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | AKT1 | P31749 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16559310 | 1.00 | PPARA (0.43) | PPARASYKRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6852186 | 0.81 | NPC1 (0.51) | PPARASYKRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL21201525 | 0.79 | ATM (0.44) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL16561964 | 0.78 | CTSK (0.36) | ALDH1A1KMT2A | |
| SCHEMBL16577823 | 0.78 | CTSK (0.36) | ALDH1A1KMT2A | |
| SCHEMBL16578523 | 0.78 | GAA (0.41) | RAB9ASMN1; SMN2NPC1ALDH1A1MEN1 | |
| SCHEMBL20877907 | 0.78 | ALDH1A1 (0.42) | RAB9ASMN1; SMN2NPC1ALDH1A1MEN1 | |
| SCHEMBL16559321 | 0.78 | ALDH1A1 (0.42) | RAB9ASMN1; SMN2NPC1ALDH1A1MEN1 | |
| SCHEMBL22704140 | 0.77 | NPC1 (0.40) | PPARARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL25037571 | 0.77 | MAPT (0.39) | RAB9ASMN1; SMN2NPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210186969-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Biopharma, Inc. (US) | 2021-06-24 | — | — | US | disclosed |
| US-10980805-B2 | Aza-pyridone compounds and uses thereof | Janssen Biopharma, Inc. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200030328-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Biopharma, Inc. (US) | 2020-01-30 | — | — | US | disclosed |
| US-10251882-B2 | Aza-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2019-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200030328-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | PPARA 1459/4885SYK 3092/4885RAB9A 1824/4885 |
| US-10980805-B2 | Aza-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | PPARA 1459/4885SYK 3092/4885RAB9A 1824/4885 |
| US-10251882-B2 | Aza-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | PPARA 1459/4885SYK 3092/4885RAB9A 1824/4885 |
| US-20210186969-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | PPARA 1459/4885SYK 3092/4885RAB9A 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.