Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14960479 | 0.88 | LMNA (0.55) | LMNAMAPTALDH1A1KMT2AHTT | |
| SCHEMBL18532547 | 0.88 | LMNA (0.55) | LMNAMAPTALDH1A1KMT2AHTT | |
| SCHEMBL25132655 | 0.88 | LMNA (0.55) | LMNAMAPTALDH1A1KMT2AHTT | |
| SCHEMBL25133886 | 0.86 | MEN1 (0.49) | LMNAMAPTKMT2AMEN1HCRTR1 | |
| SCHEMBL24016940 | 0.85 | UBE2M (0.52) | LMNAMAPTALDH1A1KMT2AHTT | |
| SCHEMBL13326615 | 0.84 | LMNA (0.49) | LMNAMAPTALDH1A1KMT2AHTT | |
| SCHEMBL12176346 | 0.84 | LMNA (0.49) | LMNAMAPTALDH1A1KMT2AHTT | |
| SCHEMBL25132781 | 0.84 | CYP2C19 (0.47) | LMNAMAPTMAPK1HCRTR1HCRTR2 | |
| SCHEMBL12176584 | 0.83 | LMNA (0.52) | LMNAMAPTALDH1A1KMT2AHTT | |
| SCHEMBL18609355 | 0.81 | ALDH1A1 (0.53) | LMNAMAPTALDH1A1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508477-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2021-11-10 | — | — | EP | disclosed |
| EP-3078658-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2019-04-10 | — | — | EP | disclosed |