SCHEMBL208874

SCHEMBL208874

COc1ccc(N(Cc2ccc([O])cc2)C(=O)OCC2c3ccccc3-c3ccccc32)c(OC)c1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ FABP5 Q01469 1/20 0.41
▸ TSHR P16473 5/20 0.38
▸ HTT P42858 1/20 0.38
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ GPR55 Q9Y2T6 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ TSPO P30536 2/20 0.36
▸ BCL2A1 Q16548 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28069712 0.93 FABP5 (0.45) FABP5TSHRHTTMEN1KMT2A
SCHEMBL4784032 0.92 FABP5 (0.41) FABP5TSHRHTTMEN1KMT2A
SCHEMBL1526171 0.91 FABP5 (0.40) FABP5TSHRHTTMEN1KMT2A
SCHEMBL6298094 0.91 FABP5 (0.42) FABP5TSHRHTTMEN1KMT2A
SCHEMBL294203 0.91 FABP5 (0.40) FABP5TSHRHTTMEN1KMT2A
SCHEMBL5372417 0.90 FABP5 (0.39) FABP5TSHRHTTMEN1KMT2A
SCHEMBL5670740 0.89 FABP5 (0.39) FABP5TSHRHTTMEN1KMT2A
SCHEMBL3433024 0.88 HSD17B10 (0.39) FABP5TSHRHTTMEN1KMT2A
SCHEMBL2637405 0.87 FABP5 (0.39) FABP5MEN1KMT2ATSPO
SCHEMBL3805522 0.87 BMP1 (0.37) FABP5TSHRHTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 597 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240218042-A1 MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE SANOFI (FR) 2024-07-04 — — US disclosed
EP-4392440-A2 COMBINATION OF RELAXIN AND VASOPRESSIN ANALOGUES FOR TREATMENT OF RENAL DISORDERS OR CONDITIONS River 2 Renal Corp. (US) 2024-07-03 — — EP disclosed
US-11992537-B2 Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy PROVINCIAL HEALTH SERVICES AUTHORITY (CA) 2024-05-28 — — US disclosed
WO-2024071320-A1 COMPOUND PRODUCTION METHOD 国立大学法人東京大学 2024-04-04 — — WO disclosed
US-20240066132-A1 NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES NOVARTIS AG (CH) 2024-02-29 — — US disclosed
WO-2023200897-A1 USE OF VIRAL IL-6 IN CANCER THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-10-19 — — WO disclosed
US-11771657-B2 Methods of delivering a neuroprotective polypeptide to the central nervous system THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-10-03 — — US disclosed
US-11752211-B2 Fatty acids and their use in conjugation to biomolecules NOVARTIS AG (CH) 2023-09-12 — — US disclosed
US-11725036-B2 Modified lipidated relaxin B chain peptides and their therapeutic use SANOFI (FR) 2023-08-15 — — US disclosed
WO-2023146807-A1 VEGF MUTANTS AND MODULATION OF INTEGRIN-MEDIATED SIGNALING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-08-03 — — WO disclosed
EP-0672679-A1 PHOSPHOLIPASE C INHIBITING PEPTIDE KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1995-09-20 — — EP disclosed
EP-0670729-A1 TREATING RETINAL NEURONAL DISORDERS BY THE APPLICATION OF INSULIN-LIKE GROWTH FACTORS AND ANALOGS CEPHALON, INC. (US) 1995-09-13 — — EP disclosed
WO-1995021194-A1 SUPERACTIVE VIP ANTAGONISTS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1995-08-10 — — WO disclosed
EP-0670729-A4 TREATING RETINAL NEURONAL DISORDERS BY THE APPLICATION OF INSULIN-LIKE GROWTH FACTORS AND ANALOGS. CEPHALON INC (US) 1995-05-10 — — EP disclosed
WO-1994021684-A1 BOTULINUM TOXIN POLYPEPTIDES AND THEIR USE AS VACCINE ENHANCING AGENTS MICROBIOLOGICAL RESEARCH AUTHORITY (GB) 1994-09-29 — — WO disclosed
EP-0604605-A1 TREATING DISORDERS BY APPLICATION OF INSULIN-LIKE GROWTH FACTORS AND ANALOGS CEPHALON, INC. (US) 1994-07-06 — — EP disclosed
WO-1994000486-A1 NEUROPEPTIDE Y ANTAGONISTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-01-06 — — WO disclosed
WO-1993020836-A1 TREATING DISORDERS BY APPLICATION OF INSULIN-LIKE GROWTH FACTORS AND ANALOGS CEPHALON, INC. (US) 1993-10-28 — — WO disclosed
WO-1993008826-A1 TREATING RETINAL NEURONAL DISORDERS BY THE APPLICATION OF INSULIN-LIKE GROWTH FACTORS AND ANALOGS CEPHALON, INC. (US) 1993-05-13 — — WO disclosed
WO-1993005011-A1 NOVEL IMMUNOSUPPRESSANTS SANDOZ LTD. (CH) 1993-03-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11992537-B2 Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy MC1R, MC5R, MC3R FABP5 3290/4885TSHR 65/4885HTT 1303/4885
US-20240066132-A1 NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES FABP1, FABP2, FABP3 FABP5 11/4885TSHR 828/4885HTT 2558/4885
US-11752211-B2 Fatty acids and their use in conjugation to biomolecules FABP1, FABP2, FABP3 FABP5 13/4885TSHR 620/4885HTT 2474/4885
US-20240218042-A1 MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE RXFP1, RXFP2, RXFP4 FABP5 141/4885TSHR 581/4885HTT 3577/4885
US-11725036-B2 Modified lipidated relaxin B chain peptides and their therapeutic use SCTR, RXFP1, RXFP3 FABP5 314/4885TSHR 40/4885HTT 3263/4885
US-11771657-B2 Methods of delivering a neuroprotective polypeptide to the central nervous system GLP1R, IAPP, BDNF FABP5 1487/4885TSHR 341/4885HTT 110/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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