Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1475852 | 0.94 | SIRT6 (0.68) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL7048817 | 0.86 | MAPT (0.85) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL1851861 | 0.84 | MAPT (0.89) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL28901607 | 0.81 | MEN1 (0.66) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL378458 | 0.81 | MAPT (0.96) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL6151230 | 0.80 | SIRT6 (0.81) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL15271381 | 0.80 | SIRT6 (0.81) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL3569406 | 0.80 | LMNA (1.00) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL85552 | 0.79 | MAPT (1.00) | LMNAMAPTSIRT6POLBALDH1A1 | |
| SCHEMBL223626 | 0.79 | MAPT (1.00) | LMNAMAPTSIRT6POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694509-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Nuvation Bio Inc. (US) | 2020-08-19 | — | — | EP | disclosed |
| WO-2019074981-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | GiraFpharma LLC (US) | 2019-04-18 | — | — | WO | disclosed |