Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20900024 | 1.00 | EGFR (0.46) | EGFRKITSCN10ASCN5AALDH1A1 | |
| SCHEMBL17516278 | 0.86 | ALDH1A1 (0.42) | EGFRALDH1A1MAPTHPGDGFER | |
| SCHEMBL16355448 | 0.85 | SCN10A (0.41) | EGFRSCN10ASCN5AMAPTNLN | |
| SCHEMBL19323265 | 0.83 | TRPV1 (0.44) | EGFRSCN10ASCN5ANLN | |
| SCHEMBL20900140 | 0.83 | MASP2 (0.55) | — | |
| SCHEMBL18480825 | 0.83 | MASP2 (0.55) | — | |
| Hydrochloric Acid SCHEMBL18438992 | 0.81 | MASP2 (0.53) | — | |
| SCHEMBL10254066 | 0.81 | HPGDS (0.49) | SCN10ASCN5ANLN | |
| SCHEMBL12159164 | 0.80 | HPGDS (0.44) | SCN10ASCN5ANLN | |
| SCHEMBL12107481 | 0.80 | NLN (0.48) | SCN10ASCN5ANLN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11732005-B2 | Peptidomimetic proteasome inhibitors | CORNELL UNIVERSITY (US) | 2023-08-22 | — | — | US | disclosed |
| US-11732005-B2 | Peptidomimetic proteasome inhibitors | CORNELL UNIVERSITY (US) | 2023-08-22 | — | — | US | disclosed |
| US-20220056073-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | UNIV CORNELL (US) | 2022-02-24 | — | — | US | disclosed |
| US-20220056073-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | UNIV CORNELL (US) | 2022-02-24 | — | — | US | disclosed |
| US-11203613-B2 | Peptidomimetic proteasome inhibitors | CORNELL UNIVERSITY | 2021-12-21 | — | — | US | disclosed |
| US-11203613-B2 | Peptidomimetic proteasome inhibitors | CORNELL UNIVERSITY | 2021-12-21 | — | — | US | disclosed |
| US-20200317729-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | CORNELL UNIVERSITY | 2020-10-08 | — | — | US | disclosed |
| US-20200317729-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | CORNELL UNIVERSITY | 2020-10-08 | — | — | US | disclosed |
| EP-3694605-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | Cornell University (US) | 2020-08-19 | — | — | EP | disclosed |
| WO-2019075252-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | CORNELL UNIVERSITY (US) | 2019-04-18 | — | — | WO | disclosed |
| WO-2019075252-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | CORNELL UNIVERSITY (US) | 2019-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200317729-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | PSMB1, PSMB3, PSMB11 | EGFR 2143/4885KIT 3584/4885SCN10A 4133/4885 |
| US-20220056073-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | PSMB1, PSMB3, PSMB11 | EGFR 2200/4885KIT 3583/4885SCN10A 4127/4885 |
| US-11203613-B2 | Peptidomimetic proteasome inhibitors | PSMB1, PSMB3, PSMB11 | EGFR 2143/4885KIT 3584/4885SCN10A 4133/4885 |
| US-11732005-B2 | Peptidomimetic proteasome inhibitors | PSMB1, PSMB3, PSMB11 | EGFR 2200/4885KIT 3583/4885SCN10A 4127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.