Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.57 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.57 |
| ▸ | IAPP | P10997 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29550982 | 0.84 | TRPV1 (0.58) | ERCC1ERCC4MAPTHSD17B10TRPV1 | |
| SCHEMBL19084777 | 0.83 | IAPP (0.63) | ERCC1ERCC4IAPPMAPTHSD17B10 | |
| SCHEMBL107219 | 0.81 | MAPT (0.71) | ERCC1ERCC4MAPTHSD17B10TRPV1 | |
| SCHEMBL108102 | 0.81 | ERCC1 (0.82) | ERCC1ERCC4IAPPHSD17B10TRPV1 | |
| SCHEMBL10029412 | 0.80 | MAPT (0.70) | ERCC1ERCC4IAPPMAPTHSD17B10 | |
| SCHEMBL15924294 | 0.79 | MAPT (0.61) | ERCC1ERCC4MAPTHSD17B10TRPV1 | |
| SCHEMBL9444688 | 0.79 | IAPP (0.62) | ERCC1ERCC4IAPPMAPTHSD17B10 | |
| SCHEMBL18273964 | 0.79 | ERCC1 (0.57) | ERCC1ERCC4IAPPMAPTHSD17B10 | |
| SCHEMBL18232229 | 0.78 | MTNR1A (0.40) | ERCC1ERCC4TRPV1MEN1KMT2A | |
| SCHEMBL21586450 | 0.78 | POLB (0.44) | ERCC1ERCC4HSD17B10TRPV1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10259777-B2 | (E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn-1-yl)acrylamide for treatment of neurodegenerative diseases | THE UNIVERSITY OF HONG KONG (CN) | 2019-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10259777-B2 | (E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn-1-yl)acrylamide for treatment of neurodegenerative diseases | GAP43, BDNF, NEFM | ERCC1 3236/4885ERCC4 4321/4885IAPP 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.