SCHEMBL20901220

SCHEMBL20901220

Cn1c(N)nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c1=O

nearest known ligand 0.72

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
P2RY1 P47900 6/20 0.72
P2RX3 P56373 5/20 0.72
ENPP1 P22413 2/20 0.72
P2RY11 Q96G91 2/20 0.72
P2RX1 P51575 2/20 0.72
P2RX4 Q99571 2/20 0.72
P2RY6 Q15077 1/20 0.72
P2RY12 Q9H244 2/20 0.70
RNASEL Q05823 4/20 0.68
P2RY2 P41231 2/20 0.63
P2RX2 Q9UBL9 2/20 0.63
SRC P12931 1/20 0.63
ALDH1A1 P00352 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
GPR17 Q13304 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14928757 1.00 P2RY1 (0.72) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL14948858 1.00 P2RY1 (0.72) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL19442379 1.00 P2RY1 (0.72) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL14853693 1.00 P2RY1 (0.72) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL625113 1.00 P2RY1 (0.72) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL309060 0.99 P2RY1 (0.71) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL18950213 0.94 P2RY1 (0.63) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL17010791 0.92 CA5A (0.67) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL263421 0.92 CA5A (0.67) P2RY1P2RX3ENPP1P2RY11P2RX1
SCHEMBL15071495 0.92 CA5A (0.67) P2RY1P2RX3ENPP1P2RY11P2RX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2931319-B1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX INC (US) 2019-08-21 EP disclosed
US-10258698-B2 Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions MODERNATX, INC. (US) 2019-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10258698-B2 Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions NSUN2, RNMT, ADAR P2RY1 1666/4885P2RX3 2793/4885ENPP1 195/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.