Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30130671 | 1.00 | MEN1 (0.69) | MEN1KMT2ARAB9ANPC1HPGD | |
| Hydrochloric Acid SCHEMBL11459054 | 0.98 | MEN1 (0.67) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL27193042 | 0.85 | RAB9A (0.79) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL30851500 | 0.85 | RAB9A (0.79) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL11858223 | 0.84 | GPR35 (0.67) | MEN1KMT2ATSHRKCNK3GAA | |
| SCHEMBL4555389 | 0.84 | KMT2A (0.72) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL10883410 | 0.84 | GPR35 (0.74) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL2090931 | 0.83 | MEN1 (0.69) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL687148 | 0.82 | GAA (0.68) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL167713 | 0.82 | MEN1 (0.67) | MEN1KMT2ARAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893200-B1 | CARBAMATE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2010-09-29 | — | — | EP | claimed |
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | claimed |
| WO-2009087218-A1 | THIAZOLTRIAZOLES AND THIAZOLIMIDAZOLES AS ANTAGONISTS OF THE MGLUR5 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | claimed |
| US-20090082399-A1 | Carbamate derivatives as positive allosteric modulators of metabotropic glutamate receptors | ADDEX PHARMA SA (CH) | 2009-03-26 | — | — | US | claimed |
| EP-1212295-B1 | SUBSTITUTED ALPHA-HYDROXY ACID CASPASE INHIBITORS AND THE USE THEREOF | CYTOVIA INC (US) | 2008-10-01 | — | — | EP | claimed |
| EP-1893200-A2 | CARBAMATE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2008-03-05 | — | — | EP | claimed |
| EP-1799673-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-06-27 | — | — | EP | claimed |
| US-7166587-B2 | Carbamic acid alkyl ester derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-01-23 | — | — | US | claimed |
| WO-2006123244-A2 | CARBAMATE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2006-11-23 | — | — | WO | claimed |
| US-20060154960-A1 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2006-07-13 | — | — | US | claimed |
| WO-2006044528-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | claimed |
| CN-1235875-C | Substituted alpha-hydroxy acid caspase inhibitors and uses thereof | CYTOVIA INC (US) | 2006-01-11 | — | — | CN | claimed |
| US-20050075327-A1 | Carbamic acid alkyl ester derivatives | HOFFMAN-LA ROCHE INC. | 2005-04-07 | — | — | US | claimed |
| EP-1494700-A2 | CASPASE INHIBITORS FOR THE TREATMENT OF DISEASES AND CONDITIONS CAUSED BY EXPOSURE TO RADIONUCLIDES, BIOLOGICAL AGENTS, OR CHEMICAL AGENTS | Cytovia, Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2004002401-A2 | CASPASE INHIBITORS FOR THE TREATMENT OF DISEASES AND CONDITIONS CAUSED BY EXPOSURE TO RADIONUCLIDES, BIOLOGICAL AGENTS, OR CHEMICAL AGENTS | CYTOVIA, INC. (US) | 2004-01-08 | — | — | WO | claimed |
| CN-1382119-A | Substituted alpha-hydroxy acid caspase inhibitors and uses thereof | CYTOVIA INC (US) | 2002-11-27 | — | — | CN | claimed |
| EP-4323338-A1 | TEAD INHIBITORS | Orion Corporation (FI) | 2024-02-21 | — | — | EP | disclosed |
| US-20230027752-A1 | OPIOID RECEPTOR AGONIST, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | FUDAN UNIVERSITY (CN) | 2023-01-26 | — | — | US | disclosed |
| CN-1382119-A | Substituted alpha-hydroxy acid caspase inhibitors and uses thereof | CYTOVIA INC (US) | 2002-11-27 | — | — | CN | disclosed |
| US-5866596-A | DRUGS WITH ANTIINFLAMMATORY AND ANALGESIC PROPERTIES. | LABORATORIES UPSA (FR) | 1999-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075327-A1 | Carbamic acid alkyl ester derivatives | BCHE, CHRM1, ADCY7 | MEN1 1340/4885KMT2A 2212/4885RAB9A 83/4885 |
| US-20090082399-A1 | Carbamate derivatives as positive allosteric modulators of metabotropic glutamate receptors | GRM5, GRIK5, GRM1 | MEN1 4636/4885KMT2A 1223/4885RAB9A 723/4885 |
| US-20230027752-A1 | OPIOID RECEPTOR AGONIST, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | OPRM1, OPRD1, OPRL1 | MEN1 4579/4885KMT2A 1648/4885RAB9A 1910/4885 |
| US-20060154960-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE4B, PDE12 | MEN1 4070/4885KMT2A 1669/4885RAB9A 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.