Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.54 |
| ▸ | RELA | Q04206 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FOS | P01100 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1816274 | 0.88 | SYK (0.69) | SYKSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| Alcohol SCHEMBL22518598 | 0.86 | SYK (0.66) | SYKSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL1991090 | 0.82 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1RAB9ANPC1NFKB1 | |
| SCHEMBL2908655 | 0.82 | RAB9A (0.56) | SMN1; SMN2ALDH1A1RAB9ANPC1NFKB1 | |
| SCHEMBL7024255 | 0.81 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1RAB9ANPC1NFKB1 | |
| SCHEMBL21160728 | 0.80 | RAB9A (0.55) | SYKSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL7017546 | 0.80 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1RAB9ANPC1NFKB1 | |
| SCHEMBL1014833 | 0.78 | SMN1; SMN2 (0.59) | SYKSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL19158921 | 0.77 | MAPT (0.46) | SYKSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL22860593 | 0.77 | ALDH1A1 (0.44) | SYKSMN1; SMN2ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210381-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2019074979-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | GIRAFPHARMA, LLC (US) | 2019-04-18 | — | — | WO | disclosed |