Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024255 | 0.87 | ALDH1A1 (0.55) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL423187 | 0.86 | MEN1 (0.64) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL29897636 | 0.86 | MEN1 (0.64) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL7017546 | 0.85 | ALDH1A1 (0.54) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL1991090 | 0.85 | SMN1; SMN2 (0.76) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL20910144 | 0.82 | SYK (0.55) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL15212266 | 0.81 | ALDH1A1 (0.60) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL1669574 | 0.79 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL30996914 | 0.79 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 | |
| SCHEMBL9591338 | 0.78 | RGS12 (0.47) | RAB9ASMN1; SMN2NPC1ALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660011-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2020-06-03 | — | — | EP | disclosed |
| US-9663497-B2 | Benzoimidazol-2-yl pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-30 | — | — | US | disclosed |
| US-20160340337-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | NOVASSAY S.A. (CH) | 2016-11-24 | — | — | US | disclosed |
| US-9434715-B2 | Benzoimidazol-2-yl pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-06 | — | — | US | disclosed |
| US-9365548-B2 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-14 | — | — | US | disclosed |
| US-20160159775-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-09 | — | — | US | disclosed |
| US-9278952-B2 | Benzoimidazol-2-yl pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-08 | — | — | US | disclosed |
| EP-2964229-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2016-01-13 | — | — | EP | disclosed |
| US-20150148361-A1 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2015-05-28 | — | — | US | disclosed |
| US-8962644-B2 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2015-02-24 | — | — | US | disclosed |
| US-20130072510-A1 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (US) | 2013-03-21 | — | — | US | disclosed |
| US-8343989-B2 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-01 | — | — | US | disclosed |
| US-20100256373-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | EDWARDS JAMES P | 2010-10-07 | — | — | US | disclosed |
| EP-2007752-B1 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-18 | — | — | EP | disclosed |
| US-20090137608-A1 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | EDWARDS JAMES P | 2009-05-28 | — | — | US | disclosed |
| EP-2007752-A4 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-22 | — | — | EP | disclosed |
| US-7507737-B2 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4receptor | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-03-24 | — | — | US | disclosed |
| EP-2007752-A2 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007117399-A2 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-18 | — | — | WO | disclosed |
| US-20070244126-A1 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244126-A1 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | HRH4, HRH2, HRH3 | RAB9A 3687/4885SMN1; SMN2 4496/4885NPC1 3712/4885 |
| US-20160340337-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | RAB9A 2719/4885SMN1; SMN2 4441/4885NPC1 2570/4885 |
| US-20160159775-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | RAB9A 2719/4885SMN1; SMN2 4441/4885NPC1 2570/4885 |
| US-20090137608-A1 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | HRH4, HRH2, HRH3 | RAB9A 3828/4885SMN1; SMN2 4580/4885NPC1 3835/4885 |
| US-20100256373-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH2, HRH3 | RAB9A 3828/4885SMN1; SMN2 4580/4885NPC1 3835/4885 |
| US-20150148361-A1 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | HRH4, HRH2, HRH3 | RAB9A 3687/4885SMN1; SMN2 4496/4885NPC1 3712/4885 |
| US-20130072510-A1 | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | HRH4, HRH2, HRH3 | RAB9A 3828/4885SMN1; SMN2 4580/4885NPC1 3835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.