Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17807494 | 0.81 | NOS2 (0.50) | MAPK10NOS2MAPK14 | |
| SCHEMBL17807492 | 0.81 | NOS2 (0.53) | MAPK10NOS2CHRNB4CHRNA3MAPK9 | |
| SCHEMBL16865684 | 0.78 | NOS2 (0.50) | MAPK10NOS2CHRNB4CHRNA3NISCH | |
| SCHEMBL17807495 | 0.78 | NOS2 (0.46) | NOS2KDM4EMAPT | |
| SCHEMBL16866585 | 0.77 | MAPK10 (0.49) | MAPK10NOS2NISCHKDM4ESMN1; SMN2 | |
| SCHEMBL1969339 | 0.76 | MAPK10 (0.61) | MAPK10NOS2CHRNB4CHRNA3NISCH | |
| SCHEMBL12158615 | 0.72 | NOS2 (0.50) | MAPK10NOS2NISCHMAPK9 | |
| SCHEMBL31344191 | 0.72 | NOS2 (0.46) | NOS2NISCHCYP11B1CYP11B2 | |
| SCHEMBL693705 | 0.69 | ACHE (0.42) | CHRNB4CHRNA3NISCHKDM4EMEN1 | |
| SCHEMBL16866584 | 0.69 | NOS2 (0.46) | NOS2NISCHKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-02-27 | — | — | US | disclosed |
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-02-27 | — | — | US | disclosed |
| EP-3471723-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | Memorial Sloan Kettering Cancer Center (US) | 2019-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | HHAT, SHH, MBOAT1 | MAPK10 828/4885NOS2 3357/4885CHRNB4 4683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.