Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20914719 | 0.84 | ALDH1A1 (0.41) | ALDH1A1NPC1HSD11B1LMNARECQL | |
| SCHEMBL19475183 | 0.77 | CDK2 (0.43) | ALDH1A1HSD11B1CA12CA1CA2 | |
| SCHEMBL29653709 | 0.76 | ALDH1A1 (0.45) | ALDH1A1NPC1MEN1KMT2ACA2 | |
| SCHEMBL4924795 | 0.74 | ALDH1A1 (0.53) | ALDH1A1NPC1HSD11B1MEN1KMT2A | |
| SCHEMBL20914725 | 0.73 | ALDH1A1 (0.49) | ALDH1A1NPC1HSD11B1RECQLRAB9A | |
| SCHEMBL20914717 | 0.71 | ALDH1A1 (0.50) | ALDH1A1NPC1HSD11B1LMNAKMT2A | |
| SCHEMBL20914736 | 0.69 | ALDH1A1 (0.41) | ALDH1A1NPC1HSD11B1LMNACA2 | |
| SCHEMBL2422395 | 0.68 | TRPA1 (0.52) | ALDH1A1LMNAMEN1KMT2ARAB9A | |
| SCHEMBL29843543 | 0.68 | ALDH1A1 (0.59) | ALDH1A1NPC1HSD11B1LMNATP53 | |
| SCHEMBL11226379 | 0.67 | PLCG1 (0.60) | ALDH1A1NPC1RECQLCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190119241-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119241-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NLRP1, NLRP3, NOD1 | ALDH1A1 2176/4885NPC1 51/4885JAK2 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.