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SCHEMBL20920484

SCHEMBL20920484

O=C(O)c1nn(C(=O)N2C[C@H]3C[C@H](Oc4cccc(-c5ccccc5)c4)C[C@H]3C2)cc1C(F)(F)F

nearest known ligand 0.65

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 8/20 0.65
▸ MGLL Q99685 14/20 0.61
▸ TRPA1 O75762 1/20 0.39
▸ SLC16A3 O15427 1/20 0.39
▸ SLC16A1 P53985 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30420889 1.00 FAAH (0.65) FAAHMGLLTRPA1SLC16A3SLC16A1
SCHEMBL25643997 1.00 FAAH (0.65) FAAHMGLLTRPA1SLC16A3SLC16A1
SCHEMBL20920436 0.86 FAAH (0.68) FAAHMGLL
SCHEMBL20920432 0.86 FAAH (0.68) FAAHMGLLSLC16A3SLC16A1
SCHEMBL30420205 0.86 FAAH (0.68) FAAHMGLL
SCHEMBL24969877 0.86 FAAH (0.68) FAAHMGLLSLC16A3SLC16A1
SCHEMBL24235891 0.82 FAAH (0.54) FAAHMGLL
SCHEMBL25830299 0.81 FAAH (0.65) FAAHMGLLSLC16A3SLC16A1
SCHEMBL25830347 0.81 FAAH (0.64) FAAHMGLLSLC16A3SLC16A1
SCHEMBL20920431 0.79 FAAH (1.00) FAAHMGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230219897-A1 PYRAZOLE MAGL INHIBITORS H. LUNDBECK A/S (DK) 2023-07-13 — — US disclosed
US-20230219897-A1 PYRAZOLE MAGL INHIBITORS H. LUNDBECK A/S (DK) 2023-07-13 — — US disclosed
EP-4198024-A1 PYRAZOLE MAGL INHIBITORS H. Lundbeck A/S (DK) 2023-06-21 — — EP disclosed
US-11655217-B2 Pyrazole MAGL inhibitors H. LUNDBECK A/S (DK) 2023-05-23 — — US disclosed
US-11655217-B2 Pyrazole MAGL inhibitors H. LUNDBECK A/S (DK) 2023-05-23 — — US disclosed
US-20220031676-A1 METHODS OF TREATING DISEASE WITH MAGL INHIBITORS H. LUNDBECK A/S (DK) 2022-02-03 — — US disclosed
US-20210053960-A1 PYRAZOLE MAGL INHIBITORS H. LUNDBECK A/S (DK) 2021-02-25 — — US disclosed
US-10927105-B1 Pyrazole MAGL inhibitors LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2021-02-23 — — US disclosed
WO-2020112905-A1 METHODS OF TREATING DISEASE WITH MAGL INHIBITORS LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2020-06-04 — — WO disclosed
US-10266497-B2 Pyrazole MAGL inhibitors ABIDE THERAPEUTICS, INC. (US) 2019-04-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219897-A1 PYRAZOLE MAGL INHIBITORS MGLL, PNLIP, LPL FAAH 33/4885MGLL 1/4885TRPA1 404/4885
US-10266497-B2 Pyrazole MAGL inhibitors MGLL, PNLIP, LPL FAAH 33/4885MGLL 1/4885TRPA1 404/4885
US-20210053960-A1 PYRAZOLE MAGL INHIBITORS MGLL, PNLIP, LPL FAAH 33/4885MGLL 1/4885TRPA1 404/4885
US-20220031676-A1 METHODS OF TREATING DISEASE WITH MAGL INHIBITORS MGLL, LIPA, PNLIP FAAH 67/4885MGLL 1/4885TRPA1 4708/4885
US-11655217-B2 Pyrazole MAGL inhibitors MGLL, PNLIP, LPL FAAH 32/4885MGLL 1/4885TRPA1 466/4885
US-10927105-B1 Pyrazole MAGL inhibitors MGLL, PNLIP, LPL FAAH 33/4885MGLL 1/4885TRPA1 404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.