SCHEMBL20923723

SCHEMBL20923723

Cc1cc(-c2ccncc2)c(C#N)cc1-n1c2ccccc2c2ccc(-c3ccccc3C#N)cc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.38
PDE10A Q9Y233 1/20 0.37
PPARG P37231 2/20 0.37
XDH P47989 1/20 0.37
GSK3A P49840 1/20 0.37
GSK3B P49841 1/20 0.37
HPGD P15428 3/20 0.37
KDM4E B2RXH2 2/20 0.37
PDE5A O76074 1/20 0.37
LMNA P02545 1/20 0.37
TSHR P16473 1/20 0.37
PTGS1 P23219 1/20 0.37
PDE4A P27815 1/20 0.37
CYP2C19 P33261 1/20 0.37
BLM P54132 1/20 0.37
PDE4B Q07343 1/20 0.37
PDE4C Q08493 1/20 0.37
PDE4D Q08499 1/20 0.37
PDE3B Q13370 1/20 0.37
PDE3A Q14432 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20924131 0.97 TRPA1 (0.40) TRPA1PDE10APPARGXDHGSK3A
SCHEMBL20924030 0.96 PDE10A (0.37) TRPA1PDE10APPARGXDHGSK3A
SCHEMBL20924130 0.94 TRPA1 (0.38) TRPA1PDE10APPARGXDHGSK3A
SCHEMBL20924111 0.94 AR (0.39) TRPA1XDHHPGDKDM4EPDE5A
SCHEMBL20924031 0.93 HPGD (0.39) TRPA1PDE10AXDHGSK3AGSK3B
SCHEMBL19909024 0.92 TRPA1 (0.41) TRPA1PDE10APPARGXDHGSK3A
SCHEMBL20924121 0.91 CYP11B1 (0.39) XDHHPGDKDM4EPDE5ALMNA
SCHEMBL20923560 0.91 SQOR (0.40) XDHGSK3AGSK3BHPGDKDM4E
SCHEMBL20923321 0.91 NR3C1 (0.40) TRPA1PDE10APPARGXDHGSK3A
SCHEMBL20924125 0.91 AR (0.41) TRPA1XDHHPGDKDM4EPDE5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3266772-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-04-24 EP disclosed