Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 5/20 | 0.33 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27099133 | 0.77 | OPRM1 (0.40) | PNMTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3973946 | 0.77 | PNMT (0.52) | PNMTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30555211 | 0.77 | PNMT (0.52) | PNMTGRIN2DGRIN3BGRIN1GRIN2A | |
| Bromide SCHEMBL25318949 | 0.76 | OPRM1 (0.39) | PNMTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL17582390 | 0.73 | MAOB (0.46) | PNMTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL21220171 | 0.72 | MEN1 (0.40) | PNMTMEN1KMT2AMAOB | |
| SCHEMBL1107788 | 0.71 | MAOB (0.45) | PNMTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2710992 | 0.70 | PNMT (0.46) | PNMTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23141412 | 0.69 | FAAH (0.56) | MEN1KMT2A | |
| SCHEMBL21220542 | 0.69 | PNMT (0.62) | PNMTGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970104-B1 | BICYCLIC ANALGESIC COMPOUNDS | ZENO ROYALTIES & MILESTONES LLC (US) | 2019-04-24 | — | — | EP | disclosed |