Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23141412 | 0.83 | FAAH (0.56) | MEN1KMT2AFAAHL3MBTL1CYP2C19 | |
| SCHEMBL22362680 | 0.83 | ATF4 (0.44) | MEN1KMT2AHDAC4 | |
| SCHEMBL4212248 | 0.80 | KMT2A (0.60) | MEN1KMT2AFAAHSMN1; SMN2EPHX2 | |
| SCHEMBL22362684 | 0.79 | LMNA (0.48) | KMT2ASMN1; SMN2L3MBTL1CYP1A2EPHX2 | |
| SCHEMBL30407874 | 0.79 | FAAH (0.46) | MEN1KMT2AFAAH | |
| SCHEMBL21238259 | 0.77 | DPP8 (0.43) | MEN1KMT2AMAOBL3MBTL1HTT | |
| SCHEMBL23141350 | 0.74 | KDM4E (0.51) | KMT2AFAAH | |
| SCHEMBL17467926 | 0.72 | AKR1C1 (0.47) | MEN1KMT2AHDAC4AKR1C1PNMT | |
| SCHEMBL20925330 | 0.72 | PNMT (0.40) | MEN1KMT2APNMTMAOB | |
| SCHEMBL27099133 | 0.72 | OPRM1 (0.40) | MEN1KMT2APNMTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023069708-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND USES THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| US-11242327-B2 | Analgesic compounds | RECURIUM IP HOLDINGS, LLC (US) | 2022-02-08 | — | — | US | disclosed |
| US-20220033394-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN | ALKERMES, INC. | 2022-02-03 | — | — | US | disclosed |
| US-11180455-B2 | Compounds for the treatment of pain | ALKERMES, INC. | 2021-11-23 | — | — | US | disclosed |
| EP-3749667-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN | Alkermes, Inc. (US) | 2020-12-16 | — | — | EP | disclosed |
| US-20200270221-A1 | ANALGESIC COMPOUNDS | KTHERA, LLC | 2020-08-27 | — | — | US | disclosed |
| US-20200255383-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2020-08-13 | — | — | US | disclosed |
| US-10604489-B2 | Compounds for the treatment of pain | ALKERMES, INC. (US) | 2020-03-31 | — | — | US | disclosed |
| WO-2019152946-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN | ALKERMES, INC. (US) | 2019-08-08 | — | — | WO | disclosed |
| US-20190241524-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2019-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270221-A1 | ANALGESIC COMPOUNDS | INA, IK, ACHE | MEN1 4009/4885KMT2A 4218/4885HDAC4 4010/4885 |
| US-11242327-B2 | Analgesic compounds | INA, IK, ACHE | MEN1 4009/4885KMT2A 4218/4885HDAC4 4010/4885 |
| US-10604489-B2 | Compounds for the treatment of pain | OPRK1, OPRL1, ACHE | MEN1 4653/4885KMT2A 3424/4885HDAC4 1073/4885 |
| US-20190241524-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN | OPRK1, OPRL1, ACHE | MEN1 4653/4885KMT2A 3424/4885HDAC4 1073/4885 |
| US-11180455-B2 | Compounds for the treatment of pain | OPRK1, OPRL1, ACHE | MEN1 4653/4885KMT2A 3424/4885HDAC4 1073/4885 |
| US-20220033394-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN | OPRK1, OPRL1, ACHE | MEN1 4653/4885KMT2A 3424/4885HDAC4 1073/4885 |
| US-20200255383-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN | OPRK1, OPRL1, ACHE | MEN1 4653/4885KMT2A 3424/4885HDAC4 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.