Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093581 | 0.83 | TDP1 (0.37) | TDP1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL2093022 | 0.82 | HSD17B1 (0.39) | ACHETDP1ESR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2093826 | 0.76 | ALDH1A1 (0.43) | ACHEALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL2093944 | 0.76 | TDP1 (0.40) | ACHETAAR1TDP1NFE2L2ALDH1A1 | |
| SCHEMBL2094180 | 0.75 | DDB1 (0.42) | TDP1DDB1CRBNNFE2L2ALDH1A1 | |
| SCHEMBL27930560 | 0.75 | ACHE (0.40) | ACHETAAR1TDP1DDB1CRBN | |
| SCHEMBL9462171 | 0.74 | MAPT (0.33) | TDP1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL2697490 | 0.74 | MAPT (0.33) | TDP1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL2090253 | 0.74 | C1R (0.37) | TDP1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL2697491 | 0.74 | CHEK1 (0.41) | TDP1ALDH1A1SMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662185-B | Synthesis method of N-methyl o-fluoroaniline | 江苏富鼎化学有限公司 | 2023-05-05 | — | — | CN | claimed |
| CN-113429297-A | Method for synthesizing N-methyl o-fluoroaniline by one-pot method | 江西汇和化工有限公司 | 2021-09-24 | — | — | CN | claimed |
| CN-111662185-A | Synthesis method of N-methyl o-fluoroaniline | 江苏富鼎化学有限公司 | 2020-09-15 | — | — | CN | claimed |
| CN-115197072-B | Preparation method of N-alkyl-2-fluoroaniline | 合肥星宇化学有限责任公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115160151-B | Preparation method of N-alkyl-2-fluoroaniline | 合肥星宇化学有限责任公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-116574011-A | Synthesis method of N-monomethylated aromatic amine derivative | 东南大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-111662185-B | Synthesis method of N-methyl o-fluoroaniline | 江苏富鼎化学有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-111662185-B | Synthesis method of N-methyl o-fluoroaniline | 江苏富鼎化学有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-115197072-A | Preparation method of N-alkyl-2-fluoroaniline | 合肥星宇化学有限责任公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-115160151-A | Preparation method of N-alkyl-2-fluoroaniline | 合肥星宇化学有限责任公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-113429297-A | Method for synthesizing N-methyl o-fluoroaniline by one-pot method | 江西汇和化工有限公司 | 2021-09-24 | — | — | CN | disclosed |
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-8163753-B2 | 2-(4-(4-(4-chlorophenyl)oxazol-2-yl)phenoxymethyl)-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole; bactericide; excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-04-24 | — | — | US | disclosed |
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |
| US-20080119478-A1 | 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis | OTSUKA PHAMACEUTICAL CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | ACHE 4670/4885TAAR1 364/4885TDP1 4666/4885 |
| US-20080119478-A1 | 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis | NR2C2, NR0B2, NR4A2 | ACHE 4734/4885TAAR1 163/4885TDP1 4548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.