Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060240 | 0.84 | ALDH1A1 (0.47) | L3MBTL1KMT2AKDM4EALDH1A1GFER | |
| SCHEMBL4061177 | 0.84 | L3MBTL1 (0.47) | L3MBTL1KMT2AKDM4EALDH1A1GFER | |
| SCHEMBL16572388 | 0.82 | ALDH1A1 (0.68) | L3MBTL1KMT2AKDM4EALDH1A1GFER | |
| SCHEMBL5510459 | 0.82 | ALDH1A1 (0.68) | L3MBTL1KMT2AKDM4EALDH1A1GFER | |
| SCHEMBL22299557 | 0.81 | KMT2A (0.49) | L3MBTL1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11176717 | 0.79 | ALDH1A1 (0.49) | L3MBTL1KMT2AKDM4EALDH1A1GFER | |
| SCHEMBL22299266 | 0.78 | KMT2A (0.49) | L3MBTL1KMT2AMEN1 | |
| SCHEMBL11192385 | 0.77 | ABCB1 (0.58) | L3MBTL1KDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL8251470 | 0.76 | CYP2D6 (0.47) | L3MBTL1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL18889194 | 0.76 | CYP2D6 (0.47) | L3MBTL1KMT2AKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3699179-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2020-08-26 | — | — | EP | disclosed |
| WO-2019076336-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2019-04-25 | — | — | WO | disclosed |