Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL773429 | 0.85 | CA1 (0.55) | NR4A2TSHRLMNAALDH1A1CFTR | |
| SCHEMBL8156698 | 0.82 | NR4A2 (0.49) | NR4A2TSHRLMNAALDH1A1CFTR | |
| SCHEMBL11101842 | 0.81 | NR4A2 (0.47) | NR4A2TSHRLMNAALDH1A1CFTR | |
| SCHEMBL22426557 | 0.80 | KMT2A (0.42) | NR4A2TSHRLMNAALDH1A1CFTR | |
| SCHEMBL23987486 | 0.79 | LMNA (0.48) | NR4A2TSHRLMNAALDH1A1CFTR | |
| SCHEMBL2950918 | 0.78 | TSHR (0.53) | NR4A2TSHRLMNAALDH1A1CFTR | |
| SCHEMBL8907310 | 0.78 | CA1 (0.46) | NR4A2TSHRLMNAALDH1A1CFTR | |
| SCHEMBL31345289 | 0.78 | NR4A2 (0.45) | NR4A2TSHRLMNAALDH1A1CFTR | |
| SCHEMBL403705 | 0.77 | CA12 (0.64) | NR4A2TSHRLMNAALDH1A1CA1 | |
| SCHEMBL1666445 | 0.77 | CA1 (0.64) | TSHRLMNAALDH1A1CFTRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079701-A1 | HETEROBIFUNCTIONAL COMPOUNDS WITH IMPROVED SPECIFICITYFOR THE BROMODOMAIN OF BRD4 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-25 | — | — | WO | disclosed |