Sugi Predict

Sugi Predict / Compounds / SCHEMBL403705

SCHEMBL403705

SCHEMBL403705

COC(=O)c1c(C)cccc1C

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 1/20 0.64
▸ CA1 P00915 1/20 0.64
▸ CA2 P00918 1/20 0.64
▸ CA7 P43166 1/20 0.64
▸ CA9 Q16790 1/20 0.64
▸ CA14 Q9ULX7 1/20 0.64
▸ NR4A2 P43354 2/20 0.49
▸ CYP3A4 P08684 2/20 0.48
▸ ACHE P22303 1/20 0.48
▸ TSHR P16473 3/20 0.48
▸ LMNA P02545 4/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.46
▸ HPGD P15428 1/20 0.46
▸ HTT P42858 1/20 0.44
▸ MAPT P10636 2/20 0.44
▸ POLB P06746 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL70172 0.91 CA12 (0.59) CA12CA1CA2CA7CA9
SCHEMBL773429 0.87 CA1 (0.55) CA12CA1CA2CA7CA9
SCHEMBL9545793 0.87 CA12 (0.80) CA12CA1CA2CA7CA9
SCHEMBL30320392 0.86 CA12 (0.57) CA12CA1CA2CA7CA9
SCHEMBL833170 0.86 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL30632216 0.86 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL543900 0.86 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL8056782 0.86 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL7213192 0.86 CA12 (0.57) CA12CA1CA2CA7CA9
SCHEMBL485070 0.86 CA12 (0.53) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115895623-B Asphaltene deposition inhibitor composition and preparation method and application thereof 中国石油化工股份有限公司 2023-12-12 — — CN claimed
CN-115895623-A Asphaltene deposition inhibitor composition, and preparation method and application thereof 中国石油化工股份有限公司 2023-04-04 — — CN claimed
US-20080311051-A1 Caspase-2 Inhibitors And Their Biological Applications THERAPTOSIS SA (FR) 2008-12-18 — — US claimed
EP-1740614-A2 CASPASE-2 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS Theraptosis S.A. (FR) 2007-01-10 — — EP claimed
WO-2005105829-A2 CASPASE-2 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS THERAPTOSIS S.A. (FR) 2005-11-10 — — WO claimed
EP-0187462-B1 SUPPORTED OLEFIN POLYMERIZATION CATALYST AMOCO CORPORATION (US) 1990-04-25 — — EP claimed
EP-0187462-A2 Supported olefin polymerization catalyst AMOCO CORPORATION (US) 1986-07-16 — — EP claimed
US-4581342-A COMPLEX OF MAGNESIUM ALKYL COMPOUND WITH HINDERED AROMATIC ACID ESTER STANDARD OIL COMPANY (INDIANA) (US) 1986-04-08 — — US claimed
US-12006321-B2 Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists Sanford Burnham Prebys Medical Discovery Institute (US) 2024-06-11 — — US disclosed
CN-117460736-A Nucleoside derivatives having multi-target phosphorylase inhibitory activity and pharmaceutical compositions for preventing and treating cancer comprising the same 未来制药有限公司 2024-01-26 — — CN disclosed
WO-2024018471-A1 CATHEPSIN INHIBITORS AND USE THEREOF IN A METHOD FOR DETECTING AND TREATING RESISTANCE TO IMMUNOTHERAPY YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-01-25 — — WO disclosed
CN-115895623-B Asphaltene deposition inhibitor composition and preparation method and application thereof 中国石油化工股份有限公司 2023-12-12 — — CN disclosed
US-20230111853-A1 COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION ORIONIS BIOSCIENCES, INC. 2023-04-13 — — US disclosed
CN-115895623-A Asphaltene deposition inhibitor composition, and preparation method and application thereof 中国石油化工股份有限公司 2023-04-04 — — CN disclosed
US-4585788-A 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives AMERICAN HOECHST CORPORATION (US) 1986-04-29 — — US disclosed
US-4581342-A COMPLEX OF MAGNESIUM ALKYL COMPOUND WITH HINDERED AROMATIC ACID ESTER STANDARD OIL COMPANY (INDIANA) (US) 1986-04-08 — — US disclosed
US-4128556-A COMPLEXING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1978-12-05 — — US disclosed
US-4080337-A Multioxymacrocycle compounds containing pyridyl rings as part of the macrocycle THE UPJOHN COMPANY (US) 1978-03-21 — — US disclosed
US-3965116-A COMPLEXING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1976-06-22 — — US disclosed
US-3943153-A BACTERICIDES MERCK & CO., INC. (US) 1976-03-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230111853-A1 COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION CRBN, STUB1, ADRM1 CA12 4120/4885CA1 3613/4885CA2 4399/4885
US-20080311051-A1 Caspase-2 Inhibitors And Their Biological Applications CASP1, CASP2, CASP9 CA12 4601/4885CA1 2682/4885CA2 1881/4885
US-12006321-B2 Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists APLNR, AP3B1, AGTR1 CA12 4871/4885CA1 4781/4885CA2 4673/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.