Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768476 | 0.87 | CYP2C9 (0.40) | CYP2C9EPHX2 | |
| SCHEMBL4400851 | 0.75 | HSD11B1 (0.36) | HSD11B1 | |
| Adamantane SCHEMBL935449 | 0.74 | HSD11B1 (0.48) | HSD11B1CYP2C9TSHRL3MBTL1HSD17B10 | |
| Adamantane SCHEMBL974954 | 0.74 | HSD11B1 (0.48) | HSD11B1CYP2C9TSHRL3MBTL1HSD17B10 | |
| Adamantane SCHEMBL3981833 | 0.74 | HSD11B1 (0.48) | HSD11B1CYP2C9TSHRL3MBTL1HSD17B10 | |
| Adamantane SCHEMBL679263 | 0.73 | LMNA (0.62) | HSD11B1CYP2C9TSHRHSD17B10THRB | |
| Adamantane SCHEMBL30013496 | 0.73 | LMNA (0.62) | HSD11B1CYP2C9TSHRHSD17B10THRB | |
| Adamantan-2-Ol SCHEMBL28007882 | 0.71 | CYP2C9 (0.59) | HSD11B1CYP2C9TSHRL3MBTL1HSD17B10 | |
| SCHEMBL5321034 | 0.71 | CYP2C9 (0.42) | HSD11B1CYP2C9TSHRL3MBTL1HSD17B10 | |
| Acrylic Acid SCHEMBL27529960 | 0.70 | LMNA (0.43) | HSD11B1CYP2C9TSHRL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626216-B2 | High glass transition temperature polycarbonates derived from adamantane epoxides | PROMERUS, LLC (US) | 2020-04-21 | — | — | US | disclosed |
| US-20190127522-A1 | HIGH GLASS TRANSITION TEMPERATURE POLYCARBONATES DERIVED FROM ADAMANTANE EPOXIDES | PROMERUS, LLC (US) | 2019-05-02 | — | — | US | disclosed |