Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.37 |
| ▸ | ELOVL3 | Q9HB03 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20945254 | 0.97 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL20945097 | 0.84 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL20945293 | 0.76 | TSHR (0.61) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL20945090 | 0.70 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL20945265 | 0.69 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL5265409 | 0.69 | L3MBTL1 (0.47) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL20945323 | 0.69 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA3ALDH1A1 | |
| SCHEMBL20945311 | 0.69 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL28702102 | 0.69 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL20945301 | 0.68 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478671-B1 | PYRIDAZINONE-BASED BROAD SPECTRUM ANTI-INFLUENZA INHIBITORS | HOFFMANN LA ROCHE (CH) | 2020-05-13 | — | — | EP | disclosed |
| US-10597380-B2 | Pyridazinone-based broad spectrum anti-influenza inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190127349-A1 | PYRIDAZINONE-BASED BROAD SPECTRUM ANTI-INFLUENZA INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127349-A1 | PYRIDAZINONE-BASED BROAD SPECTRUM ANTI-INFLUENZA INHIBITORS | ABCG2, PIR, PRNP | GABRA1 1845/4885GABRG2 2456/4885GABRB3 1967/4885 |
| US-10597380-B2 | Pyridazinone-based broad spectrum anti-influenza inhibitors | ABCG2, PIR, PRNP | GABRA1 1845/4885GABRG2 2456/4885GABRB3 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.