Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10946405 | 0.77 | TRPV1 (0.53) | CCNA2CDK2CCNA1DAO | |
| SCHEMBL20945293 | 0.72 | TSHR (0.61) | L3MBTL1POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL22864545 | 0.70 | POLB (0.62) | L3MBTL1POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL19120983 | 0.70 | SMN1; SMN2 (0.53) | L3MBTL1POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL20945097 | 0.69 | GABRA1 (0.50) | L3MBTL1POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL20945254 | 0.69 | GABRA1 (0.62) | L3MBTL1POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL20944974 | 0.69 | GABRA1 (0.59) | L3MBTL1POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL8721198 | 0.69 | POLB (0.49) | L3MBTL1POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL254957 | 0.68 | MAPT (0.56) | L3MBTL1PIM1PIM2NOTUMEPHX2 | |
| SCHEMBL3006629 | 0.68 | MGLL (0.58) | L3MBTL1POLBMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833800-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |