Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 15/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.58 |
| ▸ | LMNA | P02545 | 8/20 | 0.58 |
| ▸ | HPGD | P15428 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 9/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29920589 | 0.86 | MAPT (0.67) | MAPTKDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL20966354 | 0.86 | MAPT (0.67) | MAPTKDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL20945436 | 0.86 | HIF1A (0.66) | HIF1AMAPTKDM4ELMNAHPGD | |
| SCHEMBL20966315 | 0.83 | HIF1A (0.53) | HIF1AMAPTKDM4ELMNAHPGD | |
| SCHEMBL29920521 | 0.83 | NPY5R (0.68) | HIF1AMAPTKDM4ELMNAHPGD | |
| SCHEMBL20966399 | 0.83 | NPY5R (0.68) | HIF1AMAPTKDM4ELMNAHPGD | |
| SCHEMBL29920894 | 0.81 | NPY5R (0.66) | HIF1AMAPTKDM4ELMNAHPGD | |
| SCHEMBL20966314 | 0.81 | NPY5R (0.66) | HIF1AMAPTKDM4ELMNAHPGD | |
| SCHEMBL4725265 | 0.76 | NPY5R (0.72) | HIF1AMAPTKDM4ELMNAHPGD | |
| SCHEMBL4729061 | 0.75 | RORC (0.70) | MAPTKDM4ELMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11446299-B2 | Carbazole EHop-016 derivatives as anticancer and anti-migratory agents | UNIVERSITY OF PUERTO RICO (US) | 2022-09-20 | — | — | US | disclosed |
| US-11446299-B2 | Carbazole EHop-016 derivatives as anticancer and anti-migratory agents | UNIVERSITY OF PUERTO RICO (US) | 2022-09-20 | — | — | US | disclosed |
| US-20200352941-A1 | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS | UNIV PUERTO RICO (US) | 2020-11-12 | — | — | US | disclosed |
| US-10729689-B2 | Carbazole EHop-016 derivatives as anti-cancer and anti-migratory agents | UNIVERSITY OF PUERTO RICO (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190125746-A1 | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS | UNIVERSITY OF PUERTO RICO (PR) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200352941-A1 | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS | CDC42, ARHGEF2, ARHGDIB | HIF1A 3566/4885MAPT 4054/4885KDM4E 3338/4885 |
| US-11446299-B2 | Carbazole EHop-016 derivatives as anticancer and anti-migratory agents | CDC42, ARHGEF2, HRAS | HIF1A 3643/4885MAPT 3790/4885KDM4E 3473/4885 |
| US-20190125746-A1 | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS | CDC42, ARHGEF2, HRAS | HIF1A 3783/4885MAPT 3896/4885KDM4E 3107/4885 |
| US-10729689-B2 | Carbazole EHop-016 derivatives as anti-cancer and anti-migratory agents | CDC42, ARHGEF2, GDI2 | HIF1A 3561/4885MAPT 3908/4885KDM4E 3363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.