SCHEMBL20969575

SCHEMBL20969575

CC(c1ccc(C(=O)O)cc1)N(CCc1ccc(Cl)cc1Cl)c1nc2cccc(F)c2s1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 3/20 0.37
COPS5 Q92905 1/20 0.36
PTGDR Q13258 2/20 0.35
NR4A2 P43354 2/20 0.35
PTGER4 P35408 4/20 0.34
CCR4 P51679 2/20 0.34
MBOAT4 Q96T53 1/20 0.33
NR4A1 P22736 1/20 0.33
NR4A3 Q92570 1/20 0.33
CMKLR1 Q99788 1/20 0.33
MC4R P32245 1/20 0.33
MC5R P33032 1/20 0.33
MC3R P41968 1/20 0.33
MRGPRX4 Q96LA9 2/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GABRA1 P14867 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20969556 0.87 TRPM8 (0.41) TRPM8PTGDRGABRA1
SCHEMBL20969677 0.86 TRPM8 (0.37) TRPM8PTGER4GABRA1
SCHEMBL20969706 0.84 TRPM8 (0.37) TRPM8PTGER4GABRA1
SCHEMBL20969741 0.83 KARS1 (0.38) TRPM8PTGER4
SCHEMBL20969611 0.83 MRGPRX4 (0.34) TRPM8PTGER4MRGPRX4
SCHEMBL20969727 0.83 TRPM8 (0.35) TRPM8PTGER4GABRA1
SCHEMBL20969694 0.82 KARS1 (0.45) COPS5PTGDRNR4A2MBOAT4NR4A1
SCHEMBL20969612 0.82 TAAR1 (0.34) TRPM8PTGER4
SCHEMBL20969684 0.81 TRPM8 (0.34) TRPM8GABRA1
SCHEMBL20969728 0.81 KARS1 (0.38) TRPM8PTGER4GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP claimed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US claimed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US claimed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP claimed
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP disclosed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US disclosed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US disclosed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same ILK, SBDS, BDKRB1 TRPM8 772/4885COPS5 939/4885PTGDR 408/4885
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same ILK, SBDS, BDKRB1 TRPM8 772/4885COPS5 939/4885PTGDR 408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.