SCHEMBL20969679

SCHEMBL20969679

COc1ccc(CCN(Cc2ccc(C(=O)O)cc2)c2nc3cccc(C)c3s2)cc1

nearest known ligand 0.71

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KARS1 Q15046 1/20 0.71
LPAR1 Q92633 5/20 0.48
LPAR5 Q9H1C0 5/20 0.48
TAS2R14 Q9NYV8 5/20 0.47
PPARD Q03181 6/20 0.45
PPARG P37231 2/20 0.43
PTGES O14684 1/20 0.41
TAS2R8 Q9NYW2 1/20 0.41
CXCR3 P49682 1/20 0.41
NPC1 O15118 1/20 0.41
POLB P06746 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PPARA Q07869 1/20 0.41
ACHE P22303 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20969689 0.91 KARS1 (0.71) KARS1LPAR1LPAR5TAS2R14PPARD
SCHEMBL20969573 0.90 KARS1 (0.70) KARS1LPAR1LPAR5TAS2R14PPARD
SCHEMBL20969695 0.90 KARS1 (0.70) KARS1LPAR1LPAR5TAS2R14PPARD
SCHEMBL20969682 0.90 KARS1 (0.70) KARS1LPAR1LPAR5TAS2R14PPARD
SCHEMBL20969609 0.87 KARS1 (0.67) KARS1LPAR1LPAR5TAS2R14PPARD
SCHEMBL20969566 0.87 KARS1 (0.64) KARS1LPAR1LPAR5TAS2R14PPARD
SCHEMBL20969673 0.87 KARS1 (0.66) KARS1LPAR1LPAR5TAS2R14PPARD
SCHEMBL20969600 0.84 KARS1 (0.65) KARS1LPAR1LPAR5TAS2R14PPARD
SCHEMBL20969634 0.84 KARS1 (0.51) KARS1LPAR1LPAR5TAS2R14PPARG
SCHEMBL20969655 0.82 KARS1 (0.69) KARS1LPAR1LPAR5TAS2R14PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP claimed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US claimed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US claimed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP claimed
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP disclosed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US disclosed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US disclosed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same ILK, SBDS, BDKRB1 KARS1 6/4885LPAR1 567/4885LPAR5 670/4885
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same ILK, SBDS, BDKRB1 KARS1 6/4885LPAR1 567/4885LPAR5 670/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.