Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 14/20 | 0.45 |
| ▸ | KDM6B | O15054 | 7/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KDM4A | O75164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2346372 | 0.77 | KDM4C (0.55) | KDM4CKDM6BKDM4DTDP1KDM4E | |
| SCHEMBL20976770 | 0.77 | ALDH1A1 (0.45) | TDP1KDM4EALDH1A1MAPTNAPRT | |
| SCHEMBL5014069 | 0.73 | KDM4C (0.49) | KDM4CKDM6BKDM4DTDP1KDM4E | |
| SCHEMBL21118610 | 0.72 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTGAATSHR | |
| SCHEMBL17746099 | 0.71 | KDM4C (0.47) | KDM4CKDM6BKDM4DTDP1KDM4E | |
| SCHEMBL3392091 | 0.69 | KDM4C (0.62) | KDM4CKDM6BKDM4DTDP1KDM4E | |
| SCHEMBL30923484 | 0.69 | KDM4C (0.62) | KDM4CKDM6BKDM4DTDP1KDM4E | |
| SCHEMBL11870062 | 0.69 | KDM4C (0.62) | KDM4CKDM6BKDM4DTDP1KDM4E | |
| SCHEMBL29416303 | 0.67 | KDM4C (0.65) | KDM4CKDM6BKDM4DTDP1KDM4E | |
| SCHEMBL71335 | 0.67 | KDM4C (0.65) | KDM4CKDM6BKDM4DTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3093291-B1 | DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-05-08 | — | — | EP | disclosed |