Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | RORA | P35398 | 2/20 | 0.34 |
| ▸ | NR5A1 | Q13285 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LPO | P22079 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20977771 | 0.88 | BRPF1 (0.33) | ALDH1A1KDM4ENPC1LPOLMNA | |
| SCHEMBL18054261 | 0.86 | TNF (0.37) | ALDH1A1KDM4EMAPTLPOLMNA | |
| SCHEMBL20224104 | 0.83 | LPO (0.35) | ALDH1A1TSHRKDM4EMAPTLPO | |
| SCHEMBL20977762 | 0.83 | ACACB (0.36) | TSHRKDM4ELMNAMEN1KMT2A | |
| SCHEMBL18052994 | 0.82 | LRRK2 (0.36) | ALDH1A1TSHRLRRK2MAPTMAPK1 | |
| SCHEMBL18054196 | 0.80 | PTGDR2 (0.33) | ALDH1A1MAPTLPOLMNANPSR1 | |
| SCHEMBL18054178 | 0.79 | PTGDR2 (0.35) | MAPK1LMNA | |
| SCHEMBL20227289 | 0.78 | KDM4E (0.38) | ALDH1A1KDM4E | |
| SCHEMBL20224083 | 0.76 | BCHE (0.32) | — | |
| SCHEMBL20224077 | 0.75 | ALDH1A1 (0.30) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3261637-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE INC (US) | 2021-05-26 | — | — | EP | disclosed |
| EP-3261638-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE INC (US) | 2019-05-08 | — | — | EP | disclosed |