Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.31 |
| ▸ | LPO | P22079 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20227289 | 0.89 | KDM4E (0.38) | HTTALDH1A1 | |
| SCHEMBL20224077 | 0.86 | ALDH1A1 (0.30) | ALDH1A1SMYD3 | |
| SCHEMBL20977762 | 0.84 | ACACB (0.36) | HTTACACBL3MBTL1GLAMEN1 | |
| SCHEMBL18053010 | 0.84 | KDM4E (0.34) | HTTALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL18054261 | 0.83 | TNF (0.37) | HTTALDH1A1KMT2AMAPTLMNA | |
| SCHEMBL18054131 | 0.82 | HTT (0.36) | PTGDR2HTTNPSR1ACACBALDH1A1 | |
| SCHEMBL18054133 | 0.81 | ELANE (0.34) | PTGDR2HTTNPSR1ALDH1A1LMNA | |
| SCHEMBL20977760 | 0.80 | ALDH1A1 (0.36) | NPSR1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL20224104 | 0.80 | LPO (0.35) | HTTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL18054331 | 0.72 | NPSR1 (0.39) | HTTNPSR1ALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016137506-A1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE, INC. (US) | 2016-09-01 | — | — | WO | disclosed |