Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | OGG1 | O15527 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609169 | 0.80 | CYP1A1 (0.51) | SMN1; SMN2CYP2D6ALDH1A1MAPTLMNA | |
| SCHEMBL20979714 | 0.79 | ALDH1A1 (0.60) | SMN1; SMN2ALDH1A1KDM4ETSHRMAPK1 | |
| SCHEMBL1433507 | 0.78 | AOC3 (0.67) | ALDH1A1AOC2 | |
| SCHEMBL11798954 | 0.78 | MGLL (0.48) | SMN1; SMN2ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL12524169 | 0.78 | HDAC6 (0.61) | SMN1; SMN2ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL610091 | 0.77 | HPGD (0.60) | SMN1; SMN2ALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL24728688 | 0.74 | HIF1A (0.68) | SMN1; SMN2HIF1AALDH1A1KDM4ETSHR | |
| SCHEMBL24202299 | 0.73 | HDAC6 (0.56) | SMN1; SMN2ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL19380011 | 0.72 | NCF1 (0.46) | SMN1; SMN2ALDH1A1MAPTKDM4EHPGD | |
| Dioxane SCHEMBL28874690 | 0.72 | HIF1A (0.53) | SMN1; SMN2MPOCYP3A4KDM5ABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010915-B1 | SUBSTITUTED (3-(5-CHLORO-2-HYDROXYPHENYL)-1-BENZOYL-1H-PYRAZOLE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2019-05-08 | — | — | EP | disclosed |