Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | AOC2 | O75106 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22213036 | 0.88 | ALDH1A1 (0.49) | ALDH1A1KDM4EAOC2SMN1; SMN2NPC1 | |
| SCHEMBL21241844 | 0.86 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL21241801 | 0.83 | KDM4E (0.50) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL6266252 | 0.83 | KDM4E (0.58) | ALDH1A1KDM4EAOC2SMN1; SMN2NPC1 | |
| SCHEMBL29398704 | 0.83 | KDM4E (0.58) | ALDH1A1KDM4EAOC2SMN1; SMN2NPC1 | |
| SCHEMBL20826224 | 0.81 | HSD17B10 (0.63) | ALDH1A1KDM4EKMT2APOLBHSD17B10 | |
| SCHEMBL20979715 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KDM4EAOC2SMN1; SMN2NPC1 | |
| SCHEMBL6261306 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KDM4EAOC2SMN1; SMN2NPC1 | |
| SCHEMBL20979642 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KDM4EAOC2SMN1; SMN2NPC1 | |
| SCHEMBL19249879 | 0.80 | LOXL2 (0.49) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010915-B1 | SUBSTITUTED (3-(5-CHLORO-2-HYDROXYPHENYL)-1-BENZOYL-1H-PYRAZOLE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2019-05-08 | — | — | EP | disclosed |