Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20979707 | 0.86 | ALDH1A1 (0.54) | SMN1; SMN2KMT2APOLBGAAHSD17B10 | |
| SCHEMBL21241801 | 0.85 | KDM4E (0.50) | SMN1; SMN2KMT2APOLBGAAHSD17B10 | |
| SCHEMBL10294737 | 0.81 | MAP1LC3B (0.49) | SMN1; SMN2KMT2APOLBL3MBTL1GAA | |
| SCHEMBL9713054 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2APOLBL3MBTL1GAA | |
| SCHEMBL13001977 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2APOLBL3MBTL1GAA | |
| SCHEMBL13754029 | 0.78 | ALDH1A1 (0.49) | SMN1; SMN2KMT2APOLBL3MBTL1GAA | |
| SCHEMBL20826224 | 0.77 | HSD17B10 (0.63) | KMT2APOLBL3MBTL1GAAHSD17B10 | |
| SCHEMBL19249879 | 0.76 | LOXL2 (0.49) | SMN1; SMN2KMT2APOLBHSD17B10MEN1 | |
| SCHEMBL13702339 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2APOLBL3MBTL1GAA | |
| SCHEMBL13702275 | 0.76 | KDM4E (0.62) | SMN1; SMN2KMT2APOLBL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |