SCHEMBL20980458

SCHEMBL20980458

c1ccc(-n2ccnc2-c2cccc3cc4cccn4cc23)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK9 P45984 1/20 0.37
MAPK10 P53779 1/20 0.37
CYP1A2 P05177 4/20 0.33
CYP3A4 P08684 4/20 0.33
CYP2D6 P10635 4/20 0.33
CYP2C9 P11712 4/20 0.33
CYP2C19 P33261 4/20 0.33
L3MBTL1 Q9Y468 4/20 0.33
SMN1; SMN2 Q16637 4/20 0.33
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
HTR2C P28335 2/20 0.33
HTR2A P28223 1/20 0.33
ALDH1A1 P00352 3/20 0.33
POLB P06746 2/20 0.33
KDM4E B2RXH2 2/20 0.33
MAPT P10636 2/20 0.33
P2RX4 Q99571 2/20 0.32
ALOX15B O15296 2/20 0.32
GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25713147 0.81 CYP3A4 (0.37) MAPK9MAPK10CYP1A2CYP3A4CYP2D6
SCHEMBL19961723 0.79 HTR2C (0.46) MAPK9MAPK10CYP1A2CYP3A4CYP2D6
SCHEMBL20980492 0.76 RECQL (0.48) SMN1; SMN2NPC1RAB9AALDH1A1KDM4E
SCHEMBL20980547 0.74 NPC1 (0.38) MAPK9MAPK10CYP1A2CYP3A4CYP2D6
SCHEMBL20980524 0.70 ALDH1A1 (0.37) MAPK9MAPK10CYP1A2CYP3A4CYP2D6
SCHEMBL20980515 0.70 GRM4 (0.32) L3MBTL1SMN1; SMN2NPC1RAB9AHTR2C
SCHEMBL27729314 0.70 HTR2C (0.46) MAPK9MAPK10HTR2CHTR2AALDH1A1
SCHEMBL19353774 0.68 CYP3A4 (0.50) MAPK9MAPK10CYP1A2CYP3A4CYP2D6
SCHEMBL20980484 0.67 RECQL (0.48) RAB9AALDH1A1KDM4EGAAHTT
SCHEMBL29040464 0.66 MAPK9 (0.53) MAPK9MAPK10CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11685756-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-06-27 US disclosed
US-11214587-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2022-01-04 US disclosed
US-20190135843-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2019-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11685756-B2 Organic electroluminescent materials and devices OCIAD1, OCIAD2, OPRD1 MAPK9 2514/4885MAPK10 2207/4885CYP1A2 1270/4885
US-11214587-B2 Organic electroluminescent materials and devices OCIAD1, OCIAD2, OPRD1 MAPK9 2514/4885MAPK10 2207/4885CYP1A2 1270/4885
US-20190135843-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, OPRD1 MAPK9 2514/4885MAPK10 2207/4885CYP1A2 1270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.